Get your health question answered instantly from our pool of 18000+ doctors from over 80 specialties
167 Doctors Online

By proceeding, I accept the Terms and Conditions

Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

HCM Blog Instant Access to Doctors
HCM BlogQuestions Answered
HCM Blog Satisfaction
Article Home Adult and Senior Health Pulmonary Eosinophilia

Pulmonary Eosinophilia

Publisher
4339 Views
Pulmonary Eosinophilia is inflammation of the lungs associated with an increase in blood or tissue esinophils. Eosinophilia is due to extrinsic or intrinsic factors. Symptoms range from none at all to severe.

 

Causes

Extrinsic eosinophilic syndrome

Loeffler syndrome- it’s a hypersensitivity response to an ingested or inhaled antigen from food, medication, or an infectious agent

  • Parasitic infections- Round worm and hook worm infestation, Microfilarials, Schistosomiasis and Strongyloidiasis
  • Tropical pulmonary eosinophilia- Wuchereria bancrofti or Brugia malayi infestations leading to lymphatic filariasis
  • Fungal infections- Allergic bronchopulmonary aspergillosis (ABPA) is an immunologic response to Aspergillus fungus
  • Bronchocentric granulomatosis
  • Asthma can cause pulmonary eosinophilia
  • Drugs like sulfonamides, Nonsteroidal anti-inflammatory drugs, L-tryptophan, antidepressants, and contraceptives

Intrinsic eosinophilic syndrome

Signs and symptoms

Toxic products released from eosinophils causes damage to respiratory epithelium and causes bronchus constriction.

  • Chest pain
  • Dry cough
  • Wheezing
  • Low grade fever
  • Shortness of breathe
  • Rashes
  • Weight loss and fatigue
  • Pruritus dermatitis- itching
  • Hurried respiratory rate

Pulmonary Eosinophilia

Tests and diagnosis

  • Complete blood count with absolute eosinophil count (AEC). Normal blood AEC is as high as 250/µL.
  • Sputum examination, broncho alveolar lavage, and bronchoscopy
  • Stool for ova and cyst
  • IgE levels- Levels of less than 1000 ng/mL are usually seen in association with asthma and low-intensity infections.
  • IgE levels more than 2000 ng/ml are typically associated ABPA and parasitic infections.
  • Chest X-ray and CT chest
  • Pulmonary function test

Treatment

  • Supplemental oxygen of 5-6 lts
  • Bronchodilators – Salbutamol, Albuterol as injectable and inhalational route
  • Inhaled steroids is also helpful
  • Rarely systemic steroids (Prednisone and Methyl prednisolone) are required
  • Remove the potential offending medications or ingested substances.
  • Antiparasitic agents- Albendazole, Mebendazole, Praziquantel, and Ivermectin
  • Antifungal agents- Itracanazole, Flucanazole and Amphotericin -B