Drugs that cause ototoxicity (hearing loss) are aminoglycosides, vancomycin, cisplatin, loop diuretics, Quinine, salicylates. 

Drugs that cause hyperpigmentation especially on long-term muse are anticancer drugs (busulfan, cyclophosphamide, 5-fluorouracil), minocycline, chlorpromazine, amiodarone, clofazimine.

Important drugs that cause disulfiram like reaction (nausea, facial flushing, low BP, palpitation, sweating) when taken with alcohol include Cephalosporins (cefamandole, cefmenoxine, cefmetazole, cefoperazone, cefotetan, ceftriaxone), Chloramphenicol, isoniazid, Ketoconazole, Nitroimidazoles (benznidazole, metronidazole, ornidazole, tinidazole), cotrimoxazole, Sulfonylureas (chlorpropamide, glyburide, tolbutamide)