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What Causes High Thyroglobulin Levels While On Cymbalta?

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Posted on Mon, 11 Jul 2016
Question: I am 39 and have had numerous issues over the past ten to fifteen years. I have had vaginitis (pain during sex), hair thinning, terrible depression and anxiety, a feeling of a lump in my throat,heart palpitations, pain down both of my arms (I do have a hurt shoulder from an incident about two years ago when I was putting my son's bed together, but this was the whole way down both), pain up my neck, migraines, fatigue, tingling hands, etc. Many of these things have resolved themselves over the years, but I am recently still having tremors and anxiety and depression. I'm currently on Celexa (about 6 years), but I'm not sure it helps much. A few months back, my doctor changed me to Cymbalta and I got 10x worse and went back to Celexa. Before that I was on Zoloft. A doctor once did a bunch of tests and diagnosed me with PCOs. He was the only doctor to ever listen to me, but I was never sold that was the issue. I was on Metformin for a while, but stopped, since my numbers were all normal. He left his practice and I now have a doctor that continues to suggest therapy, but I KNOW there's something wrong. I went recently to a clinical nutritionist who ordered a bunch of blood work. I was tested for hypothyroid (I have been in the past, too, it's always been normal), fatigue, systemic candida, PCOs, and some other things. This time, it came back that my thyroglobin was high and that I was very low in Vitamin D. These were the only "off" results. I speak with him again this week, but I am really scared about the high thyroglobin. I asked my doctor about it (the nutritionist is 3 hours away), but he just told me I needed to go back to the nutritionist (I think he's mad I went to him). Can you explain to me why my thyroglobulin may be high but the rest of my thyroid numbers are in the normal range? Of course when I do a Google search, I'm reading about thyroid cancer, and it's scaring me.
doctor
Answered by Dr. Mirjeta Guni (1 hour later)
Brief Answer:
You do not have to be worried.

Detailed Answer:
Welcome and thank you for asking on HCM.

I have gone carefully through your concern.

Thyroglobulin may be high in many pathologies of the thyroid gland. It is not specific for thyroid cancer.

It is primarily used as a tumor marker to evaluate the effectiveness of treatment for thyroid cancer and to monitor the recurrence. So it has a high value after having been diagnosed with thyroid cancer.

In your case i would recommend to do an ultrasound of the thyroid gland and to see the structure (the presence of nodules or thyroiditis.

Even if there is found a nodule in ultrasound, it doesn' t mean that it is cancer because it may be raised in benign nodules too.

That is why thyroglobulin today is used only as a tumor marker after being diagnosed with cancer to monitor the recurrences.

The fact that other exams are within the normal ranges means that the thyroid function is normal but there is a thyroiditis or a nodule that has raised the thyroglobulin, that is why the ultrasound would be of help.

Hope I was clear and helpful.
please close and rate the answer if you do not have further follow up questions.

Kind regards,
Dr.Mirjeta
Note: For more information on hormonal imbalance symptoms or unmanaged diabetes with other comorbid conditions, get back to us & Consult with an Endocrinologist. Click here to book an appointment.

Above answer was peer-reviewed by : Dr. Raju A.T
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Answered by
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Dr. Mirjeta Guni

Endocrinologist

Practicing since :2006

Answered : 2414 Questions

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What Causes High Thyroglobulin Levels While On Cymbalta?

Brief Answer: You do not have to be worried. Detailed Answer: Welcome and thank you for asking on HCM. I have gone carefully through your concern. Thyroglobulin may be high in many pathologies of the thyroid gland. It is not specific for thyroid cancer. It is primarily used as a tumor marker to evaluate the effectiveness of treatment for thyroid cancer and to monitor the recurrence. So it has a high value after having been diagnosed with thyroid cancer. In your case i would recommend to do an ultrasound of the thyroid gland and to see the structure (the presence of nodules or thyroiditis. Even if there is found a nodule in ultrasound, it doesn' t mean that it is cancer because it may be raised in benign nodules too. That is why thyroglobulin today is used only as a tumor marker after being diagnosed with cancer to monitor the recurrences. The fact that other exams are within the normal ranges means that the thyroid function is normal but there is a thyroiditis or a nodule that has raised the thyroglobulin, that is why the ultrasound would be of help. Hope I was clear and helpful. please close and rate the answer if you do not have further follow up questions. Kind regards, Dr.Mirjeta