Get your health question answered instantly from our pool of 18000+ doctors from over 80 specialties
137 Doctors Online

By proceeding, I accept the Terms and Conditions

Dr. Andrew Rynne
Dr. Andrew Rynne

Family Physician

Exp 50 years

HCM Blog Instant Access to Doctors
HCM BlogQuestions Answered
HCM Blog Satisfaction
Article Home Skin Disorders Paget's disease of the breast

Paget's disease of the breast

Paget's disease of the breast is a rare form of breast cancer, accounting for less than 5 percent of all breast cancers. Paget's disease of the breast starts in the breast ducts and extends to the skin of the nipple and to the dark circle of skin (areola) around the nipple. Paget's disease of the breast isn't related to Paget's disease of the bone, a metabolic bone disease.

Paget's disease of the breast occurs most often in women over age 50. Most women with Paget's disease of the breast have underlying infiltrating ductal breast cancer.

  • Paget's disease of the nipple also occurs at other sites, most often in the groin or perianal area (extramammary Paget's disease)
  • The bladder, anus, and rectum are the most common sites
  • Extramammary Paget's disease is a rare intraepithelial adenocarcinoma of apocrine gland–bearing sites


  • Flaky or scaly skin on your nipple
  • Crusty, oozing or hardened skin resembling eczema, on the nipple, areola or both
  • Redness
  • Itching
  • A burning sensation
  • Straw-colored or bloody nipple discharge
  • A flattened or inverted nipple
  • Affected areas beyond the nipple and areola
  • A distinct lump underneath the nipple and areola
  • Skin and nipple changes usually in one breast only
  • Fluctuating skin changes early on, making it appear as if your skin is healing on its own

Risk factors

  • Older age > 50 yrs
  • A personal history of breast cancer
  • Family history of breast cancer
  • Genetic predisposition. Defects in one of several genes, especially BRCA1 or BRCA2
  • Radiation exposure
  • Excess weight
  • Exposure to estrogen- Taking estrogen, such as for hormone replacement therapy, also increases the risk of breast cancer for some women.

Tests and diagnosis

Clinical breast exam and physical exam

Mammography — an X-ray exam of your breast tissue

Breast biopsy


  • Simple mastectomy or lumpectomy
  • Ablation of overlying cutaneous involvement, either surgically or by CO2 laser ablation
  • Adjuvant therapy- anti-cancer drugs or hormone therapy to prevent a recurrence of the breast caner.

Related questions you may be interested in

doctor1 MD

Dear Doctor,   I am a 38 year old female Chinese, married with no children. I was diagnosed with Breast Cancer in early April 2014. My surgeon did...

doctor1 MD

breast discoloration can this be cancer looks like buusing purple and red I am a 53 old black woman my right brest has discoloring also looks...

doctor1 MD

I am a 62 year old generally decent health. I have type 2 diabetes for about 6 years, but is pretty well controlled ( last a1c was 6.0...

doctor1 MD

hi sir, good noon my wife has some lumps at breast area does that signs of breast cancer pls help me out i wanna take her to treatment, she is...

doctor1 MD

I am a 12 year breast cancer survivor. Last October I noticed my left breast was appearing to become smaller and I went to my doctor. A mammogram...

doctor1 MD

One year ago I had breast cancer. Just recently I have been getting pain in my back, neck and down my right arm. This week I had x-rays and then a...

doctor1 MD

I have had a bilateral mastectomy because of pagents disease. Can it reoccur in the breast area that is left behind? I have a red scaly spot about...

doctor1 MD

My son is 40 years old and is having a sericous bone problem, He s having growth growing in his joints. His right wrist was cleaned twice in...

doctor1 MD

They dr. Want to start giving my husband reclast. .. he has pagets disease. . He haas no problems of kidney trouble that we know of but his mother...

doctor1 MD

hi my mum is being investigated for paget s disease... she has been running a low grade fever for the last 25 odd days. inspite of various tests...