Hello Your spouse is taking metoprolol , sometimes this causes hypotension , rest of side effects are normal . Amlopidine causes palpitation ( this may be the reason of increased pulse rate ) , bradycardia ( this may be the reason of feeling of cold sensation ) and also causes congestive cardiac failure or C C F ( this may be the reason of cold feelings with hot sensation ). Simvastatine causes dose related myopathy (e.g myalgia , muscle weakness ). But the cause of concern is BLOOD PRESSURE in your spouse case 130 / 90 mm of Hg. Tachycardia , high blood pressure ( particularly diastolic 130 /96 ) , feeling of cold & hot sensation are concerning . The patient need to investigated with E K G and echocardiogram to isolate the case. I recommend your spouse to visit a cardiologist and sort this problem at earliest. Good luck.