Question: 63 yr old female will not leave the house,My wife has hx of anxiety from learning disability and lack of coping skills from abusive childhood. After a hospital stay in 2008 and 2004 which she was in for a severe panic frozen in fear episode. the hospitalization in 2008 and 2004 made her condition so considerably worse. she stayed in bed in 2009 for 3 months and would not leave the house and in addition they send her home medicated with 8 different psch drugs totaling over 1500mg, which included her seroquel,cymbalta,valium in addition to remeron,abilify,lexapor,ambien, halol. this is insane. They of course diagnosed her with every disease in the book. I was told that by a psychiatr that each hospitalization regresses her and is not good. It is now 2014, after a kind doctor got her of most of the stuff in 2009, she has been good on the following daily meds untill now the following; On 200mg seroquel, 4mg valium, bedtime daily. On 50 mcg synthroid, and was on 60 mg cymbalta daytime for last 8 yrs. she began a tapered down from 60 mg to 20 mg over last 12 months, 10mg every 3 months due to a bad constipation problem. Last 3 months she looked terrible, her therapist even said so. And said you looked better on your 30mg now on 20 you don't look good. Went to family doc, he gave her tylenol 3 (30/300) 2x a day for pain and ativan 0.5mg 1x A day. This was 2 months ago. Since 7 days ago she is depressed, paranoid, panic stricken, will not get out of bed till afternoon, eats when she wants to, watchs tv, plays with the cat. But the most serious she will not leave the house out of fear and panic, again, says shes scared. Please help. She will not survive a hospitalization, in 2009 she was home treated and turned around, psychiatrist got her to leave the house, it cost me$$$ for home visits. I now increased her cymbalta back to 30mg and seroquel to 300mg for sleep. she is not suicidal. The other psychiatrist is long gone, don't have the$$$ for home stuff again. IAM SCARED PLEASE HELP I DON'T WANT TO LOSE MY WIFE. The last times they threatened with state hospital for insane because insurance would not pay for 2wks each time we were lucky she got discharged. IAM SCARED IAM AFRAID THEY GO AWAY FOR GOOD. PLEASE HELP .

Another doc psychiatrist from your service agrees with you that the taper did it, he also said she may have suffered a depression relapse, she may have depression with psychotic symptoms because she is fearful of everything and will not leave the house, panic stricken, and that since her seroquel was increased to 300mg, it should be increased to 400mg. He wants to address the severe psychotic symptoms. Also he cannot explain the stomach distress and soft stool. He does not believe she has seritonin syndrome, the lipator did not cause this and can still be taken. Doc what difference then between discontinuation syndrome and relapse. Also could the ativan, tylenol 3 caused this problem, she has stopped them. Also should we keep the Valium regiment, what do I do for her Anxiety during the day and Do I aleviate the Fear factor of going out of the house. Is seroquel the answer? If she does not leave the house, then there is not doc visit, no doc visit she might be unnecessaryily hospitalized.