Child has low grade fever and puffy eyes. Mono test negative. What's wrong?
Persistent high-grade fever with a suspicious white blood count in favor of Mono, even if the test came back negative, could still be in some cases, due to Mono. Most tests generally used are not 100% effective in detecting the disease.
Other causes of fever and puffy face especially in this case need to be considered. A complete blood count might need to be re controlled. It could be interesting to know the nature of the puffy face, where it swells only in the mornings and gets to normal during the day or even, or remains swollen all day. Most cases of fever and puffy face are generally due to a kidney infection called acute glomerulonephritis, or rarely at times, a liver lesion.
Kidney function tests and liver function tests could be quite helpful in better evaluating the origin of these symptoms.
A fever evolving for over two weeks with no specific sources of infection could be evaluated to look for causes of fever of unknown origin. Detailed physical examination and other examinations like chest x rays are usually needed.
I propose you to visit a pediatrician for a more critical evaluation and some laboratory examinations for some common infectious diseases and conditions that could be involved with this fever. However, Mono is still one of the options in the diagnostic possibilities, but the addition if puffing of the face needs a more critical and specialist expertise.
Thanks as I hope this helps.
Thanks and best regards,
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