Hi there, Thanks for your query. Presence of gross obesity, menstrual irregularities since early adolescence, infertility point towards the following possibilities :- * Polycystic Ovarian Syndrome (PCOS) with possible diabetes or increased levels of insulin in the blood. Treatment of this condition can drastically increase your chances of pregnancy. * Gross Hypothyroidism, which you already have, but may not on adequate doses of thyroid hormone. The dose of thyroid hormone should be titrated so as to maintain TSH levels near its lower limit (around 0.5) Consult your doctor and apprise him of my opinion. I am ertain that he agree with me, order required tests, and- based on the reports- will prescribe suitable treatment as advised. If you find my response helpful and informative, do not forget an “excellent” rating to my answer, to encourage all doctors- engaged in social service- to render sound advice to the FREE queries. Lastly, if you need a detailed and prompt answer, you may post a Direct Query (Premium) ADDRESSED PERSONALLY TO ME BY NAME, providing AS MUCH DETAILED INFORMATION about your problem(s) as possible; age/gender; addictions (if any) ; medical history (if any); current medications (if any) and known allergies. Fond regards and have a nice day Dr. Rakesh Karanwal