Dear Welcome to HCM We understand your concerns I went through your details. I suggest you not to worry much. Depression and grief are after effects of anxiety disorder. When they realize that their anxiety is going beyond their control, the patients tend to become depressed. That is part of anxiety. Anxiety treatment considers this eventuality. Holistic anxiety therapy advices to change the life style so as to make the patient feel easy and trains in relaxation techniques. You can post a direct question to me in this website. Include all the details, whatever you can provide. I shall prescribe some psychotherapy methods which are sure to work well for your sister. Hope this answers your query. Available for further clarifications. Good luck.