Hello! Firstly have you been correctly diagnosed for Dengue fever? It is caused by the bite of AEDES mosquitoes which are also aggressive day biters recognized by their black & white stripes - transmitting the Dengue VIRUS DENV-1 to 4). PCR test for viral antigen like NS1 has 90% sensitivity (true positive for sick patient) in first week; four folds increase in Ig G antibody titres in two weeks is significant - so this is a post-treatment confirmatory test; Ig M antibody indicates previous infection. The virus does enter WBCs but infect the stromal cells in bone marrow to cause THROMBOCYTOPENIA (platelet count below 50,000 /cu mm) to cause DHF (Dengue Hemorrhagic fever) - Grade I - easy bruising/ positive tourniquet test, Grade II - spontaneous bleeding like bleeding from gums, petechial hemorrhage in shin/ legs. DHF may progress to more severe DSS (Dengue Shock Syndrome) - Grade III - clinical evidence of shock to Grade IV - blood pressure and pulse not detected due to shock. Treatment is mainly supportive by maintaining hydration orally, avoid aspirin, avoid invasive procedures; whole blood transfusion is preferred over FFP (Fresh Frozen Plasma) transfusion; platelet transfusion alone is considered when platelet count falls below 10,000/ cu mm. When IV fluids are given care should be taken to treat FLUID OVER-LOAD with diuretics especially after initial phase of the disease is over.