Hi, The medications Ciprofloxacin and Macrobid are two different medications. While nausea and tiredness can be felt after taking medications, it is important to keep a watch on the general condition of your mother. Prescribing Macrobid should be done carefully because it can affect other organs like lungs. Since she has got one kidney it is important to regularly do kidney function tests and report any breathing problems should it happen. Please confirm any other medications she is taking and this is important for her health condition. Tylenol will not cause any significant side effects. Please give her adequate fluids and she should not hold urine for a long time.