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Suggest The Ideal Dosage For MS Contin
Question: My Gp has put me on mscontine slow release 10 mill up to 60 mls per day and 2,5 of liquid Ordine for break through. I am forgetful and worry I may overdose can this be lethal and if so how much would it take.I don't want to die just yet thanks Sue my treatment is for severe restless leg RLS and I have had it for 20-30 years.
Brief Answer:
first there are a dozen other meds
Detailed Answer:
for RLS that are pretty close to non-toxic. Every Parkinson's medication and every muscle relaxant can work on RLS and are not dangerous.
Second, the units are not the usual. MSContin comes in amount not volume (milligram, not milliliter). 10 mg is lower than the usually given lowest dose (15). Ordine comes in a TEN FOLD RANGE OF DOSE! This is the highest range of almost any medicine. Similar to saying have a glass of water and that meaning anything from a dixie cup to a 2 liter bottle!
Narcotics can all be overdosed. They have a much higher safety range than other common drugs such as tylenol (5 fold), water (10 fold), oxygen (5 fold). 1 gm of tylenol is the usual extra strength, 5 gram is likely to injure the liver. 1 gallon of water is reasonable, I have had a patient have seizures from 5 gallons.
60 mg of morphine while not fatal is getting to be somewhat high. 10 mg is somewhat low. at 10 mg, I'm not sure other than allergy whether there could even be problems including addiction or withdrawal. 10 mg is quite safe; frankly compared to over the counter aspirin. Ordine is the same stuff and the same range of amount applies BUT it is PER MILLILITER (volume) so, the lowest dose 1 mg is FIVE mg if 5 Milliliter is given (one teaspoon). So, multiply all the ORDINE NUMBERS BY FIVE and that is the teaspoon dose. The ordine 2 is 10 mg per teaspoon. 10 mg is not that much. 100 mg is a lot but PROBABLY not fatal. That is the dose at ONE time not Per Day. So, a ten milligram pill once a day for a month is 300 mg, this is entirely safe since it is spread out over a month and it wears off each day (or less). Ordine wears off in about 6 hrs (or less).
If you take one long acting morphine twice a day (20 mg) and 10 mg of ordine 3 times a day (2 mg becomes 10 with one full teaspoon). that is 50 mg in one day. This is an AVERAGE dose. There is some danger of becoming addicted and dependent to it at the average dose. 100 to 200 is dangerous. That would be TEN to TWENTY of the MSCONTIN (10 fold) or TWO TO FOUR teaspoons of the highest dose of the ordine but TWENTY TO FORTY teaspoons of the lowest dose ordine.
1) make sure you know what is in the ordine
2) consider having an overdose rescue pen antidote around
3) also consider a NON-NARCOTIC drug for RLS.
Nobody uses narcotics for RLS.
first there are a dozen other meds
Detailed Answer:
for RLS that are pretty close to non-toxic. Every Parkinson's medication and every muscle relaxant can work on RLS and are not dangerous.
Second, the units are not the usual. MSContin comes in amount not volume (milligram, not milliliter). 10 mg is lower than the usually given lowest dose (15). Ordine comes in a TEN FOLD RANGE OF DOSE! This is the highest range of almost any medicine. Similar to saying have a glass of water and that meaning anything from a dixie cup to a 2 liter bottle!
Narcotics can all be overdosed. They have a much higher safety range than other common drugs such as tylenol (5 fold), water (10 fold), oxygen (5 fold). 1 gm of tylenol is the usual extra strength, 5 gram is likely to injure the liver. 1 gallon of water is reasonable, I have had a patient have seizures from 5 gallons.
60 mg of morphine while not fatal is getting to be somewhat high. 10 mg is somewhat low. at 10 mg, I'm not sure other than allergy whether there could even be problems including addiction or withdrawal. 10 mg is quite safe; frankly compared to over the counter aspirin. Ordine is the same stuff and the same range of amount applies BUT it is PER MILLILITER (volume) so, the lowest dose 1 mg is FIVE mg if 5 Milliliter is given (one teaspoon). So, multiply all the ORDINE NUMBERS BY FIVE and that is the teaspoon dose. The ordine 2 is 10 mg per teaspoon. 10 mg is not that much. 100 mg is a lot but PROBABLY not fatal. That is the dose at ONE time not Per Day. So, a ten milligram pill once a day for a month is 300 mg, this is entirely safe since it is spread out over a month and it wears off each day (or less). Ordine wears off in about 6 hrs (or less).
If you take one long acting morphine twice a day (20 mg) and 10 mg of ordine 3 times a day (2 mg becomes 10 with one full teaspoon). that is 50 mg in one day. This is an AVERAGE dose. There is some danger of becoming addicted and dependent to it at the average dose. 100 to 200 is dangerous. That would be TEN to TWENTY of the MSCONTIN (10 fold) or TWO TO FOUR teaspoons of the highest dose of the ordine but TWENTY TO FORTY teaspoons of the lowest dose ordine.
1) make sure you know what is in the ordine
2) consider having an overdose rescue pen antidote around
3) also consider a NON-NARCOTIC drug for RLS.
Nobody uses narcotics for RLS.
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
my problem is I have been on mscontin 10mgup to 5 tabs per day=50 mg and Ordine10 oral 2.5 twice a day for nearly 15 years and have now developed an allergic to it as well as it not being as effective as it was years ago. my RLS is unusual as it never leaves me and naturally we tried most other type of meds first. to day my gp has changed my meds to physeptone 0ne 10mg at night it is another opiate type drug but I have a bad reaction to sifrol(Parkinson's type drug)which we tried last week. thank you for the info on morphine I would be interested to know what other drugs if any are non narcotic for my condition keep in mind iI am a chronic sufferer, I have a spar walking strips treadmill exercise bikes and have deep muscle massage regularly I also practice yoga. and swim every day nothing helps the only reliefe I get is when my brain is concentrating on an art painting using left side of my brain helps. I have suffered this malady since 1984 and have just about reached my tether I am too old now to be working all night and would love to just sit and read sometime. thank you If I was yunger Id probably be on the hoochy grass but not my generation.
Brief Answer:
Non-narcotics.
Detailed Answer:
Ok, let us start TODAY with a magnesium supplement. It has some muscle relaxant effects. Someone with muscle cramps should be checked for electrolytes. Given the symptoms are constant, while the electrolytes vary, unless someone has a (REALLY RARE) electrolyte losing genetic condition and the condition started by teens and ....yeah, you don't have that. But magnesium is often helpful even if the level of magnesium isn't low. You need to NOT have kidney failure or the magnesium level can go too high. The degree of kidney failure would mean you would have a LOT of other problems (but not leg cramps). You don't have the kidney failure; magnesium at levels between 100 mg to 400 mg a day can be helpful.
Muscle relaxants. Robaxin and flexeril or baclofen. They need supervision.
Parkinson's drugs. Requip is the main one used; sifrol is a more expensive version of it--similar chemistry and action but a different role of the dice for reactions. Sinemet is an alternative that is somewhat dangerous in parkinson's disease and is generally not used.
Amitryptiline. Under a doctor's supervision.
Non-narcotics.
Detailed Answer:
Ok, let us start TODAY with a magnesium supplement. It has some muscle relaxant effects. Someone with muscle cramps should be checked for electrolytes. Given the symptoms are constant, while the electrolytes vary, unless someone has a (REALLY RARE) electrolyte losing genetic condition and the condition started by teens and ....yeah, you don't have that. But magnesium is often helpful even if the level of magnesium isn't low. You need to NOT have kidney failure or the magnesium level can go too high. The degree of kidney failure would mean you would have a LOT of other problems (but not leg cramps). You don't have the kidney failure; magnesium at levels between 100 mg to 400 mg a day can be helpful.
Muscle relaxants. Robaxin and flexeril or baclofen. They need supervision.
Parkinson's drugs. Requip is the main one used; sifrol is a more expensive version of it--similar chemistry and action but a different role of the dice for reactions. Sinemet is an alternative that is somewhat dangerous in parkinson's disease and is generally not used.
Amitryptiline. Under a doctor's supervision.
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
already taking magnesium supplement I don't have muscle cramps but I am compelled to walk all the time sleep for 2 hours and then need to walk again. will suggest some of your medications to my doctor who did the sleep test in hospital with the electrodes years ago and was documented as worse case sinario hence the morphine. One last question, how long will it take me to get this medication out of my system have cut dose in half for 10 days so far. Thank you (desperate to relax.
Brief Answer:
There's the medicine and the reaction
Detailed Answer:
Morphine generally wears off on its effects in 6 hours. Long acting preparations might be up to entire day longer
But, the reaction to the medicine is a very different story depending on the type of reaction. A plain allergy (hives, very common with morphine and not necessarily an allergy, morphine just causes hives) is a bit longer than the time for the drug to be gone and 3 to 5 days but an anti-histamine would work on it very soon like in 1 day. Withdrawal from morphine takes about 2 weeks to mostly be gone.
There's the medicine and the reaction
Detailed Answer:
Morphine generally wears off on its effects in 6 hours. Long acting preparations might be up to entire day longer
But, the reaction to the medicine is a very different story depending on the type of reaction. A plain allergy (hives, very common with morphine and not necessarily an allergy, morphine just causes hives) is a bit longer than the time for the drug to be gone and 3 to 5 days but an anti-histamine would work on it very soon like in 1 day. Withdrawal from morphine takes about 2 weeks to mostly be gone.
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Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
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