Get your Health question answered in 3 easy steps

161 Doctors Online
Doctor Image
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

I will be looking into your question and guiding you through the process. Please write your question below.

How long does Cotinine take to get cleared from the system?

Answered by
Dr.
Dr. Chintan Solanki

Psychiatrist

Practicing since :2007

Answered : 2406 Questions

default
Posted on Wed, 6 Aug 2014 in General Health
Question: I quit smoking cigarettes at the end of May 2014 and ended my last use of the nicotine patch at 4mg three days ago, July 16, 2014, and have to take a preop cotinine test on July 31, 2014. Will my system be clear of Cotinine by that time. I am walking twice a day for 45 minutes, eating all natural with no junk food and drinking four 16 oz bottles of water per day. I am not sure if it will be a urine or blood test but either way will that be enough time for the cotinine to be out of my system for preoperative testing. I weigh 263 pounds and this is for gastric bypass surgery. What is the normal time frame for continine to be clear from my system. What is the range of the urine versus blood test?
doctor
Answered by Dr. Chintan Solanki 41 minutes later
Brief Answer:
You are not likey to clear the test

Detailed Answer:
Hello,
Thanks for using healthcaremagic.
I read your details. After 1 month of stopping smoking and 15 days of nicotine patch you are going for testing.
Normally clearing of nicotine - cotinine from body depends upon total duration of intake, type of cigarette used and metabolism in the body. Generally it takes 1 to 4 months.
I want to know,"For how much time you have smoked and quantity of smoking."
Your weight is also high so your fat volume gonna be high which leads to later on redistribution of cotinine in the system , so I guess you are not likely clear the test.
Normal range for Urine< 0.5 ug/ml is negative and Serum/blood < 0.025 ug/ml is negative, however it sometimes varied depending upon methods used by laboratories.
Hope I have answered your query.
Regards
Dr.Chintan Solanki
Above answer was peer-reviewed by : Dr. Vinay Bhardwaj
doctor
default
Follow up: Dr. Chintan Solanki 1 hour later
Why does it take so long to clear cotinine from my system...even most testing parameters say it is cleared within 7-14 days....how do you come to this conclusion????
doctor
Answered by Dr. Chintan Solanki 31 minutes later
Brief Answer:
it depend on some factors

Detailed Answer:
Hello,

Please tell your duration and quantity of smoking.As I told I was guessing from your history that you can not clear.

Cotinine is nicotine metabolite. Nicotine deposited in fat also. And after that it slowly redistributed in circulation and metabolized in liver. If you have pretty fat/adipose tissue and if smoking is for many Years, there is possibility of appearing in circulation even after smoking up to 2-3 months.

Hope you understood what I want to convey. At end point you may clear the test also if parameter are set that nicotine patch is allowed.

Regards,
Above answer was peer-reviewed by : Dr. Raju A.T
doctor
default
Follow up: Dr. Chintan Solanki 22 minutes later
I have smoked one pack per day for 20 years. I understand what you are saying I just don't understand how something with a half-life of 20 hours is stored in fat and redistributed as fat is later broken down. Doesn't half-life refer to entire cycle of a substance??? It just seems that like a catch 22 as I am told by my physician to stop smoking and go on the patch prior to surgery and followed his instructions but then I also have to lose 10% body weight prior to surgery which will subsequently spike my cotinine levels...frustrating...bottom line the 16 days that I have will not be enough to pass the cotinine test in your opinion.
doctor
Answered by Dr. Chintan Solanki 7 hours later
Brief Answer:
Just relax, hope for the best

Detailed Answer:
Hi,
I ctan understand your frustration. But a pack for 20 years daily is really high. However in between smoking and test there is one month of gap. If your doctor is convinced that your slightly high result can be due to nicotine patch, he will agree to move forward.
So just relax, continue exercise and hope for the best. Important thing is you have quit smoking.So keep it up. If this time you will not clear, 31st August retest and you will clear and yes half life means substance appear in circulation and cleared more than 50% from quantity in circulation not in fat.
All the best & Regards.
Above answer was peer-reviewed by : Dr. Bhagyalaxmi Nalaparaju
doctor
premium_optimized

The User accepted the expert's answer

Share on
Question is related to
Drug/Medication
Medical Procedures
Lab Tests
Medical Topics ,  

Recent questions on  Liver

doctor1 MD

I need to find a good liver specialist. I saw a liver Transplant Surgeon at UCLA but that it a bit far. I also need to find a liver specialist to follow my care. I am in End Stage Liver Failure, have a TIPS plus a multitude of health issues. I am a 55 year old female

doctor1 MD

Hello. I recently had a CT bc I felt something on my liver. It turned out to be a hemangioma. In the report it also mentions a subcentimeter parenchymal cyst in my right kidney. No one even mentioned it. Does that mean it isnĀ“t important_ I have never had a kidney cyst before.

doctor1 MD

I am a 22 year old female with chronic swollen lymph nodes only on my left side,which then leads to ear pain and jaw pain. I had my tonsils taken out a little over two years ago because of chronic tonsillitis. I had blood work and the only thing that came up was that my liver enzymes were really high, they were 250. I had tests done on my live and everything came back to normal. Could my liver an lymph nodes be linked?

doctor1 MD

Hi, my husband is 34yo is has end stage liver failure and in the last 48 hours suffered with severe hiccups. Last night they last for 5 hours. They are very distressing to him and I don't know if they would be doing more damage. Is this normal? What causes this?

doctor1 MD

I HAVE TINGLING PAIN IN MY RIGHT SIDE BELOW THE RIB CAGE . BUT ONLY WHEN I SIT IT GOING COMPLETELY AWAY WHEN I LAY DOWN?

doctor1 MD

I have been taking atorvastatin 40 mg for 4 months - through carotid endarterectomy surgery - with horrible subjective side effects which, objectively, include very low hematocrit of 32.9% and other low red blood cell counts. Primary Care...

doctor1 MD

Hi Doctor, I am xxxxxxx XXXXXXX from XXXXXXX Age 38 years. Last month i have got my LFT done where SGPT was 132 and SGOT was 82 because i consume liquor on a regular basis thats why got those test done; but all of sudden i realized that last week...