Smoking can be an irritant to the oral environment. The simplest answer is to stop smoking and see the response of the uvula. Smoking can change your natural flora in the mouth. This can give you an opportunistic infection with an overabundance of certain bacteria. This could affect the uvula and require antibiotic treatment. Something such as strep throat could cause inflammation at the uvula as well. Dry mouth, mouth breathing, sleep apnea all cause some throat irritation and you could experience an inflamed, swollen uvula. There are other medical conditions such as a growth or tumor that are possible. Even an allergic reaction can be a possible response. It is wise to stop smoking and see if you feel better. I would expect a quick improvement. Your vocal cords should be happier too. If you do not feel better within a week to two weeks seek the opinion of your doctor. Anti-inflammatory medication and rinses with warm salt water may offer some immediate relief. Proper diet, no vitamin deficiencies and good hydration is a must. I hope this is helpful to you and that the simplest soltution will work out. Please let me know how you are feeling and I will be glad to answer additional questions.