Hello and welcome to Healthcare Magic. Thanks for your query. I understand that you have been going through a difficult time due to your psychiatric problem. Bipolar depression is a challenging problem to treat and often keeps recurring despite treatment. You have mentioned that you have been treated with anti-depressants and anti-psychotics. But mood stabilizers are the mainstay of treatment for Bipolar depression. There are different mood stabilizers which have been proven effective - like Lithium, Valproate, Carbamazepine, Lamotrigine, etc. Sometimes, a combination of a mood stabilizer and an antidepressant may be required. In some cases, where medication alone does not control depressive symptoms, a combination of medication and psychotherapy - like CBT can be effective. Also, in cases of resistant depression, underlying medical conditions like hypothyroidism, vitamin deficiencies, etc. may also be responsible for poor treatment response. So, I would suggest that you see a good psychiatrist and discuss about the options which I have mentioned, so that your treatment can be optimized accordingly. Wish you all the best. Regards, Dr. Jonas Sundarakumar MBBS., DPM., MRCPsych.(U.K.) Consultant Psychiatrist