Hi, thanks for the query; Has there been any improvement with Venlift (Venlafaxine) 75mg/day in your symptoms of depression or anxiety over past 3 months? If no; then the prudent strategy is hike the dose of venlift (depending upon how you are able to tolerate it without side effects & what benefits you get in the symptoms) up to max. 225mg/day. Though loose stools is a side effect of venlift but usually constipation is more common than diarrhoea. Hence we need to rule out causes like food poisoning, wheat/gluten sensitivity, some yet undignosed (in you) disease of abdomen (gastro-intestinal tract) or just another manifestation of anxiety before dose hike of venlift. Also; if you are not able to tolerate venlift & also not symptomatically improving; then there are other good options like mirtazapine, milnacipran, trazodone, buspirone etc. depending on your diagnosis & clinical profile. Lastly, in addition to medications, try to do 30 minutes/day physical exercise, get proper diet & 6-7 hours sleep. Consult your GP/Psychiatrist or get back to me for further assistance. Hope this helps; good luck