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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Side Effects Of Acitrom

Hello Doctor , My mother was operated for CA stomach cancer three months back, 15 days back she was diagnosed for DVT in left leg and advised on tab Acitrom 3mg daily, now we have found while vomiting she has vomiting blood clots like thing twice a day is it a side effect of tablet? what should be done..
Sat, 14 May 2011
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General & Family Physician 's  Response
Side effects of Acitrom:
Adverse ReactionsAs with all anticoagulants, bleeding is the major adverse effect of acenocoumarol. Hemorrhage may occur at virtually any site. Risk is dependent on multiple variables, including the intensity of anticoagulation and patient susceptibility.
Cardiovascular: Hemorrhagic shock
Central nervous system: Fever, headache, stroke (hemorrhagic)
Dermatologic: Rash, urticaria, skin necrosis
Skin necrosis/gangrene, due to paradoxical local thrombosis, is a known but rare risk of oral anticoagulant therapy. Its onset is usually within the first few days of therapy and is frequently localized to the limbs, breast, or penis. The risk of this effect is increased in patients with protein C or S deficiency.
Additional adverse reactions associated with warfarin, but likely to also occur with indanediones, include priapism and skin necrosis (“purple toe” syndrome or cutaneous gangrene).
Gastrointestinal: Gastrointestinal bleeding, melena
Genitourinary: Hematuria
Hematologic: Hemorrhage, retroperitoneal hematoma, unrecognized bleeding sites (eg, colon cancer) may be uncovered by anticoagulation. Other hematologic reactions reported with coumarin derivatives include agranulocytosis, red cell aplasia, anemia, thrombocytopenia, eosinophilia.
Hepatic: Hepatitis, hepatotoxicity, hematobilia
Ocular: Ocular hemorrhage
Respiratory: Epistaxis, hemoptysis, pulmonary hemorrhage
Miscellaneous: Hypersensitivity/allergic reactions .
but in ur moms case its difficult to comment as the disease thats cancer stomach itself can cause bleeding . consult ur dr.
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Side Effects Of Acitrom

Side effects of Acitrom: Adverse ReactionsAs with all anticoagulants, bleeding is the major adverse effect of acenocoumarol. Hemorrhage may occur at virtually any site. Risk is dependent on multiple variables, including the intensity of anticoagulation and patient susceptibility. Cardiovascular: Hemorrhagic shock Central nervous system: Fever, headache, stroke (hemorrhagic) Dermatologic: Rash, urticaria, skin necrosis Skin necrosis/gangrene, due to paradoxical local thrombosis, is a known but rare risk of oral anticoagulant therapy. Its onset is usually within the first few days of therapy and is frequently localized to the limbs, breast, or penis. The risk of this effect is increased in patients with protein C or S deficiency. Additional adverse reactions associated with warfarin, but likely to also occur with indanediones, include priapism and skin necrosis (“purple toe” syndrome or cutaneous gangrene). Gastrointestinal: Gastrointestinal bleeding, melena Genitourinary: Hematuria Hematologic: Hemorrhage, retroperitoneal hematoma, unrecognized bleeding sites (eg, colon cancer) may be uncovered by anticoagulation. Other hematologic reactions reported with coumarin derivatives include agranulocytosis, red cell aplasia, anemia, thrombocytopenia, eosinophilia. Hepatic: Hepatitis, hepatotoxicity, hematobilia Ocular: Ocular hemorrhage Respiratory: Epistaxis, hemoptysis, pulmonary hemorrhage Miscellaneous: Hypersensitivity/allergic reactions . but in ur moms case its difficult to comment as the disease thats cancer stomach itself can cause bleeding . consult ur dr.