yes you should stop estradiol
as it is causing you to form clots and it shouldnt be used with warfarin
as we are not acheiving the effect of wafarin as a blood thinner. and your inr is on the higher side you are at risk of forming clots causing a release of clot to the lungs.
estradiol increases risk of breast cancer
, clot formation, liver
disease and stroke
i would suggest you see your physician to sort you out with another medication for your hot flushes
hope have helped to answer your query
takecare and get well soon.