Hi, my husband was diagnosed with Graves' disease in April 2013 with a TSH of 0.07. He was put on PTU for a month. He had been losing a lot of weight. By end of May, his TSH was 0.02 and FT4 58.3. He took the radioactive iodine treatment (10milli curie of I 131) ablation in July 2013. In sep 2013 his values stood at T4 184.19 and anti TPO 539.6. He started gaining some weight and in Jan 2014 his TSH stood at 0.05 and FT4 at 38.84. at this point , he was prescribed Thyronorm 50 mcg once daily on empty stomach. This is when the problems started - loss of appetite, constant feverish feeling, weight loss, general feeling of Unwellness, fatigue etc. On repeating the test, we found TSH of 0.01 in Feb 2014. Are these symptoms related to the dosage of thyronorm? Out of frustration and to experiment, he has stopped thyronorm for the last three days, but the symptoms persist. What could the symptoms mean? To my understanding, a low FT4 calls for replacement therapy, but would intake of thyronorm not bring down the TSH values further? Please advise a suitable course of treatment for the current state of low TSH and low FT4.