Hello, Epilepsy can have many different origins. It may be due to stroke or vessel malformations, infection or inflammation in the brain, trauma, tumors, metabolic, brain damage during childbirth etc. So blood and imaging tests are indicated if not already done. However there is a percentage of cases where even after all tests are done the cause is not found, they remain without a known cause. So it may happen I am afraid. However, before accepting that you should discuss with the doctors how did they reach that conclusion. One single seizure doesn t make the diagnosis of epilepsy, only when there are repeat seizures. So it s unclear how did they decide that, did they see other more subtle seizures, did they see abnormal activity on EEG or epileptogenic focus on MRI? If none of that then I wouldn t be so sure about that conclusion and would seek evaluation from another neurologist. Hope I have answered your query. Let me know if I can assist you further. Regards, Dr. Olsi Taka, Neurologist