I am 52 years old, good health running daily 5K, at regular PSA at one point i got reading 4.1 . I was very scared and ask for biopsy since my readings were in range 1.9-2.2 from 2006. My wife (she is MD) ask me to do just one more test to prof that reading is accurate. After week I agree (one day before biopsy) and test come back 2.4, I was very happy until I learn that even with cancer PSA can go down, maybe not that significantly in only a week. I am scared and she thinks that everything should be OK since I have no history of cancer in family, no symptoms and two DRE from two different doctors in last month were "normal" and she insist that there is no possibility for such significant drop from 4.1 to 2.4 ("my normal") in week if the cancer is present. She said it my be some infection or my physical activity to spike it. She also do not excludes lab mistake for high reading. My only concern is that this is not cancer