Hello There can be many reasons for not responding to medication. I don t know your complete history so can only mention probable cause and you need to figure out which one you are having. One is you may be misdiagnosed and you may be having more than just depression. A combination of depression and personality disorder or bipolar disorder. Secondly you did not comply to treatment as advices and thus you develop resistance to treatment Thirdly you may have not persisted with one doctor and every new doctor advices you new treatment and you never took treatment in adequate doses and duration Fourt you may have needed augmentation treatment which your psychiatrist did not try Fifth you may have additional medical illness like thyroid problem or any other endocrine disorder or any other medication which interfere with antidepressants Sixth you may have some personal stressor which is persistant over these years and you dont have any eascape from it, which remain the main reason of your problem and you are not able to get releived