Hi, Generally it is well tolerated. Trifol-Plus is a multivitamin (folic acid, methylcobalamin and pyridoxine) formulation commonly prescribed to treat the deficiency states of these vitamins like anemia during pregnancy. Whereas trufol contains only folic acid and used to treat its deficiency states. Generally these vitamins are well tolerated however their common side effects include heartburn, nausea, bitter or bloating sensation. They are no known to cause a delayed menstrual cycle. Delayed period could be due to some other reasons like stress, recent job change, undue exercise or hormonal disturbances like thyroid or ovarian diseases. You should consult your doctor to determine the cause of delayed period and its treatment. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Mohammed Taher Ali, General & Family Physician