hi. Pyoderma gangrenosum
is one of the neutrophilic dermatosis. It usually presents as a non-healing ulcer with undermined edges and keeps on expanding.
First-line therapy pyoderma gangrenosum is systemic treatment by corticosteroids
Topical application of Clobetasol
, Mupirocin, and Gentamicin alternated with Tacrolimus can be effective.
Grafting is not recommended due to tissue necrosis.
If ineffective, alternative therapeutic procedures include systemic treatment with corticosteroids and mycophenolate mofetil; mycophenolate mofetil and cyclosporine; tacrolimus; thalidomide; infliximab; or plasmapheresis