Hi, Chronic Kidney Disease (CKD) is due to persistant underlying disease like diabetes, uncontrolled high blood presure, untreated kidney stones, rarely it may develop as a consequance to AKI (Acute Kidney Injury). In your father s case I want to know- 1) Presence of Diabetes, Blood pressure, Cholesterol problems if any and treatment taken for it. 2) Any habits like smoking, alcohol. Stage of CKD depends on eGFR (Glomerular Filtration Rate) it depends upon Age, gender, serum creatinine, weight. Treatment of CKD is to prevent or to slow the process of deterioration of kidney function. It requires- 1) Diet with adequate vegeterian proteins. 2) Control of Diabetes, blood pressure, cholesterol. 3) Avoidance of nephrotoxic food and medicines like pain killers 4) Water intake needs to be restricted if there is tendancy to retain water. 5) Low Potassium intake (avoid intake of fruit and fruit juices, coconut water) in case there is potassium retention in body. 6) Maintain calcium, phosphorus, uric acid levels under contol. 7) Avoid smoking, alcohol. 8) Screnning for complication on heart. As you have mentioned your father has got stroke it means he is at increased risk for other vascular events like heart attack (coronary artery disease) Regarding medicines you have mentioned- APLAZAAR: it is a nutritional supplement containing amino acids and other nutrients for kidney that help in mentaining kidney function but not necessarily it will avoid dialysis. ESPOGEN: It contains erythropoetin a hormone needed for hemoglobin formation and is prodused by kidney. It is used in CKD because deterioration of kidney function is associated with decreased production of erythropoetin and low hemoglobin. Treatment of CKD is to prevent or to slow the process of deterioration of kidney function. It requires- 1) Diet with adequate vegeterian proteins. 2) Control of Diabetes, blood pressure, cholesterol. 3) Avoidance of nephrotoxic food and medicines like pain killers 4) Water intake needs to be restricted if there is tendancy to retain water. 5) Low Potassium intake (avoid intake of fruit and fruit juices, coconut water) in case there is potassium retention in body. 6) Maintain calcium, phosphorus, uric acid levels under contol. 7) Avoid smoking, alcohol. Need for Haemodialysis depends on- 1) Amount of Urine production daily. 2) Serum electrolyte mainly Potassium. 3) Serum Creatinine level. 4) Arterial Blood Gas (ABG) analysis which denote degree of acid accumaulation in blood. 5) Signs of water retention like breathing difficulty, swelling over body, puffiness of face.