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What Causes Elevated Liver Enzyme While On Oxycodone And Tylenol?

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Posted on Fri, 13 Apr 2018
Question: my wife had elevated liver enzyme on recent blood test. she is in severe pain due to recent back surgeries and is taking oxycodone 5mg 3 times daily and also xtra strength Tylenol as suggested by her dr. should she stop taking the Tylenol? if so, what is her option?
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Answered by Dr. Ornela Ademovi (2 hours later)
Brief Answer:
Keep liver enzymes in check

Detailed Answer:
Hello,

I understand your concern. Both Oxycodone and Tylenol, whether separately or in combination, cause an elevation of the liver enzymes, but Tylenol is more toxic to the liver than Oxycodone.

The safe daily dose for Tylenol less then 2 grams per day, which is equal to 4 extra strength Tylenol, while gradually tapering off Oxycodone as she recovers from the surgeries.

I strongly recommend she gets the liver enzymes tested regularly to keep an eye on any changes.

I hope this helps. Wishing your wife a swift recovery.
Regards.

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Above answer was peer-reviewed by : Dr. Raju A.T
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Answered by
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Dr. Ornela Ademovi

General & Family Physician

Practicing since :2004

Answered : 725 Questions

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What Causes Elevated Liver Enzyme While On Oxycodone And Tylenol?

Brief Answer: Keep liver enzymes in check Detailed Answer: Hello, I understand your concern. Both Oxycodone and Tylenol, whether separately or in combination, cause an elevation of the liver enzymes, but Tylenol is more toxic to the liver than Oxycodone. The safe daily dose for Tylenol less then 2 grams per day, which is equal to 4 extra strength Tylenol, while gradually tapering off Oxycodone as she recovers from the surgeries. I strongly recommend she gets the liver enzymes tested regularly to keep an eye on any changes. I hope this helps. Wishing your wife a swift recovery. Regards.