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What Causes Drowsiness And Constipation After Having Naloxone?
Question: I havesevere back pain after sleeping for 2hours
I cannot sleep in bed because of the pain, I sleep with slightly less pain if I stay in my armchair
I take Targinact to obviate the excessive constipation caused by other painkillers
I have had to increase the dosage and take just 2 tablets once a day each containing 20mg oxycodone and 10 mg naloxone
I changed to TARGINACT as all other painkillers cause me severe constipation
My GP does no monitoring
I am worried for two reasons .
I have extreme sleepiness all the time
Am I taking too much naloxone?
I cannot sleep in bed because of the pain, I sleep with slightly less pain if I stay in my armchair
I take Targinact to obviate the excessive constipation caused by other painkillers
I have had to increase the dosage and take just 2 tablets once a day each containing 20mg oxycodone and 10 mg naloxone
I changed to TARGINACT as all other painkillers cause me severe constipation
My GP does no monitoring
I am worried for two reasons .
I have extreme sleepiness all the time
Am I taking too much naloxone?
Brief Answer:
no, not a bit
Detailed Answer:
No, naloxone is a BLOCKER of oxycodone action. It only can be given in TARGINAC because little/none of it gets in from the gut. It is supposed to block the action of the oxycodone on putting the gut to sleep (it blocks the narcotic action on gut that causes constipation). Personally, and in the medical literature... it doesn't work well at all to prevent constipation.
Narcotics are named that due to the Greek for sleep "narcos". The oxycontin can cause sleepiness. 40 mg of oxycodone per day is a fairly typical dose. Many people get used to it and have less sleepiness in about a week.
Chiropracty, physical therapy, different matresses, heating pads, muscle relaxers are several other modalities some have found helpful
no, not a bit
Detailed Answer:
No, naloxone is a BLOCKER of oxycodone action. It only can be given in TARGINAC because little/none of it gets in from the gut. It is supposed to block the action of the oxycodone on putting the gut to sleep (it blocks the narcotic action on gut that causes constipation). Personally, and in the medical literature... it doesn't work well at all to prevent constipation.
Narcotics are named that due to the Greek for sleep "narcos". The oxycontin can cause sleepiness. 40 mg of oxycodone per day is a fairly typical dose. Many people get used to it and have less sleepiness in about a week.
Chiropracty, physical therapy, different matresses, heating pads, muscle relaxers are several other modalities some have found helpful
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
In your reply you state that Naxolone " doesn't work well at all to prevent constipation. The manufacturers of Targinact state that it prevents constipation caused by Oxycodone. Because of this claim I changed to it from other pain killers. I have continued to take it because I have found that it does prevent the constipation caused by Oxycodone. It does it very well.
What concerns me most is the excessive sleepiness I am getting. I fall asleep at the drop of a hat. Even when I am in the loo
What concerns me most is the excessive sleepiness I am getting. I fall asleep at the drop of a hat. Even when I am in the loo
Brief Answer:
naloxone given IV
Detailed Answer:
is used to counteract narcotics and makes someone immediately go into withdrawal and very very awake. It is not absorbed orally.
On the other hand, narcotics regularly make 10's of thousands of people sleep forever per year in the U.S. alone. It's soporific effect is so characteristic that a term for using narcotics is "on the nod". 40 mg a day of oxycodone often makes people sleepy. It is not a dangerous dose. The time it takes a given pill to dissolve and act and how fast it gets in varies with the manufacturer even with the identical ingredients. Many people have problems with switching brands of narcotics because in narcotics,
but not for example antibiotics,
it isn't just if the drug gets in, but how fast and to what peak level determines how the drug feels. With the same non-dangerous not very high dose of oxycodone, with different manufacturing, the effect will feel different.
Naloxone is quite unlikely to cause drowsiness. Narcotics, which by their very name are associated with sleeping, will often give different amounts of sleepiness due to manufacturing differences even with the same exact amount of drug in every pill.
naloxone given IV
Detailed Answer:
is used to counteract narcotics and makes someone immediately go into withdrawal and very very awake. It is not absorbed orally.
On the other hand, narcotics regularly make 10's of thousands of people sleep forever per year in the U.S. alone. It's soporific effect is so characteristic that a term for using narcotics is "on the nod". 40 mg a day of oxycodone often makes people sleepy. It is not a dangerous dose. The time it takes a given pill to dissolve and act and how fast it gets in varies with the manufacturer even with the identical ingredients. Many people have problems with switching brands of narcotics because in narcotics,
but not for example antibiotics,
it isn't just if the drug gets in, but how fast and to what peak level determines how the drug feels. With the same non-dangerous not very high dose of oxycodone, with different manufacturing, the effect will feel different.
Naloxone is quite unlikely to cause drowsiness. Narcotics, which by their very name are associated with sleeping, will often give different amounts of sleepiness due to manufacturing differences even with the same exact amount of drug in every pill.
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Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
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