What is Naloxone?
Naloxone (INN, BAN, USAN) marketed under the trade name Narcan among others, is a pure opioid antagonist. Naloxone is a medication used to counter the effects of opioid especially in overdose. It will usually reverse the depression of the central nervous system, respiratory system, and hypotension. Naloxone may be combined with opioids that are taken by mouth to decrease the risk of their misuse.
Use may cause symptoms of opioid withdrawal including: agitation, nausea, vomiting, a fast heart rate and sweating among others. In those with previous heart disease further heart problems have occurred. It appears to be safe in pregnancy after having been taken by a limited number of women.
It was developed by Sankyo in the 1960s. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system. In most developed countries, naloxone is required to be present whenever opiates or opioids are administered intravenously to combat accidental overdose.