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Does nicotine cause chest pain?

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Posted on Thu, 6 Nov 2014
Question: Nicotine (via patch or gum) causes upper left chest pain but have been to hospital recently which showed I have not had a heart attack. Also, one year ago I had an echocardio test and that was normal. I'm wondering why the nicotine causes this chest pain.
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Answered by Dr. V. N. S. Parinam (2 hours later)
Brief Answer:
Nicotine patch or gum has certain unwanted effects

Detailed Answer:
Hi,

Thanks for your query.

You should understand the effects of non smoke nicotine on the heart and vessels that will further help understand the chest pain.

Nicotine acts on certain receptors of the blood vessels, acutely increase heart rate up to 10 to 15 beats/min and increase blood pressure up to 5 to 10 mm Hg. It also reduces the blood flow to the heart by constricting the blood vessels leading to the heart. Though it increases the output from the heart it regionally restricts the function of the heart muscle. Nicotine is capable of constricting coronary arteries even at low doses like 4mg in humans. It indirectly influences the platelets and lead to clot formation. It has influence over the lipids and greatly contributes the endothelial cell injury where these platelets aggregate contributing to plaque along with lipids. THis further presses over the flow to the heart and ischemic chest pain

Hope this is simple
Above answer was peer-reviewed by : Dr. Raju A.T
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Answered by
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Dr. V. N. S. Parinam

General & Family Physician

Practicing since :2008

Answered : 1731 Questions

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Does nicotine cause chest pain?

Brief Answer: Nicotine patch or gum has certain unwanted effects Detailed Answer: Hi, Thanks for your query. You should understand the effects of non smoke nicotine on the heart and vessels that will further help understand the chest pain. Nicotine acts on certain receptors of the blood vessels, acutely increase heart rate up to 10 to 15 beats/min and increase blood pressure up to 5 to 10 mm Hg. It also reduces the blood flow to the heart by constricting the blood vessels leading to the heart. Though it increases the output from the heart it regionally restricts the function of the heart muscle. Nicotine is capable of constricting coronary arteries even at low doses like 4mg in humans. It indirectly influences the platelets and lead to clot formation. It has influence over the lipids and greatly contributes the endothelial cell injury where these platelets aggregate contributing to plaque along with lipids. THis further presses over the flow to the heart and ischemic chest pain Hope this is simple