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Can Hiv Anti Bodies Remain Undetected Till 90 Days After Exposure?

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Posted on Thu, 24 Apr 2014
Question: Hi Doctor, How are you. I had a unprotected oral sex as a receiver from a lady of unknown HIV status on 24th November 2013. after that incident I have had total 8 HIV test's including 2 XXXXXXX test's .kindly see below with timing as mentioned. Received unprotected oral November 24th 2013 Putting all the test's to gether 1.rapid test after 15th day exposure -negative 2. Cmia test after 17th day exposure -negative 3. XXXXXXX after 20th day - XXXXXXX screening done for viral RNA/DNA HBV : NOT DETECTED HCV :NOT DETECTED HIV 1/2 :NOT DETECTED 4. Elisa ( 4 generation as informed by lab to me ) - 33rd day Non - Reactive . 5. XXXXXXX after 57th day - XXXXXXX screening done for viral RNA/DNA HBV : NOT DETECTED HCV :NOT DETECTED HIV 1/2 :NOT DETECTED Exactly 90 days after my exposure: 6. Rapid card which they use in my sister's blood bank =negative 7. Cmia Method ( Hiv 1 & 2 ) = .17 (Non-reactive) 8. Hiv 1 & 2 + P 24 = Negative ( In a different lab ) As far as other STD's I have done VDRL - Rapid card total 4 times 2 times I have done complete urine test I have discussed the scenario with respected Dr XXXXXXX in (HGM) already he said I am totally fine no need for further testing .So I feel bad again to ask him Doubt. Issue is 1.I am having severe cold and fever for the past 3 weeks 2.boils in my armpit 3.Rashes in hands & legs itching. 4.I have some bulgy round boil like thing in my left and right arm joint area ( is it lymp node swelling ) Doubt's: 1.I had the habit of having chewable tobacco for past 12 years can it affect my result any how. 2.I have been taking AZITHROMYCIN for the past 60 days when my test's were taken will it have any effect on my result's 3.Can Hiv anti bodies remain undetected till 90 days after the contact that to after having 8 test's. 4.The bodily condition's I am facing is it related to hiv. All the test's were done in different time and in different lab's. Regard's XXXX
doctor
Answered by Dr. Sanjay Kumar Kanodia (2 hours later)
Brief Answer: Symptoms not related to HIV Detailed Answer: Hi, Welcome and thanks for posting your query to healthcare magic. I can understand your concern for the interpretation of results of reports posted by you. After thoroughly analyzing all the reports, I first of all want to reassure you that you are not at all suffering from HIV and none of your symptoms are related to HIV, so just relax first. The first and foremost thing to tell you regarding your query is kindly rest assured about your problem as there is negligible or no risk of contracting HIV from the act of oral sex as receiving partner. Now to tell you scientifically regarding the above fact is: You do not know the status of other person- meaning whether she had HIV infection or not. So there are 50% chances of her negative status. Even if we consider positive status to HIV then you should understand that HIV is a very fragile virus and do not survive in oral mucosa (in mouth). These becomes dead as soon as it comes in contact with salivary secretions by certain enzymes in saliva. So by having oral sex even with HIV positive person does not make it sure to contract infection. It is only possible when blood from the oral mucosa of the infected person goes directly in blood of freshly cut would of the non infected person. So you can get that by oral sex the chances are itself negligible. Now even if we consider that there were if any chance of infection then your reports verify further about the totally HIV negative status of yourself. To interpret and correlate your reports: The protocol of the tests done for HIV is as follows: HIV infection can be analyzed by two ways – -A): By HIV virus detection: done by RNA- PCR. It tells us the number of copies of virus present in per ml of blood. By the latest of methods the viruses can be detected within 2 weeks of period. B): By HIV antibody Detection: the antibodies appear in maximum of 8-10 weeks then these antibodies to HIV virus persist throughout life. So if a person is tested then one HIV antibody test at 6-8 weeks and then a follow up final test at 3 months (84 days or 12 weeks) as the maximum limit. Any of these tests are not affected by any medications or antibiotics or any consumption of food or alcohol or tobacco or anything related. Now correlating all the facts let me answer all of your queries: 1.I had the habit of having chewable tobacco for past 12 years can it affect my result any how. @ No, not at all. Habit of having chewable tobacco for past 12 years can not affect test values at all. It has nothing to do with the testing. 2.I have been taking AZITHROMYCIN for the past 60 days when my test's were taken will it have any effect on my result's @ It is same for taking azithromycin too. None of the antibiotic can affect the testing of HIV. It again has nothing to do with your testing. 3.Can Hiv anti bodies remain undetected till 90 days after the contact that to after having 8 test's. @ I think you got the complete idea of testing. I personally in my own experience has never seen any body if negative at 65 days coming positive after that. So 90 days is the crystal clear limit by present day testing facilities, to declare any body as negative. 4.The bodily condition's I am facing is it related to hiv. @ Dear young man there are so many of the infections prevalent in this world which can cause similar type of illness which you have got. In my view it appears to be exaggerated upper respiratory infection which is causing all the problems. By the way azithromycin should not be consumed longer than 5 days in one course. It is totally irrational to take azithromycin for 60 days. Over and above I can make out that you are undergoing a great stress and this is one of the most important reason of getting the respiratory infection and related things prolonged. So reduce your stress otherwise it can otherwise affect your health. I personally suggest you to meet a physician at the earliest and get your self examined for the simple respiratory infection. Lastly I again reassure you for the fact that you do not have HIV infection. I hope all these informations will relax your mind. I will be glad to answer any further of your queries. Regards, Dr Sanjay Kumar Kanodia MD (Dermatology and Sexually transmitted diseases)
Above answer was peer-reviewed by : Dr. Vinay Bhardwaj
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Follow up: Dr. Sanjay Kumar Kanodia (1 hour later)
Hi sir, Thank you for the reply . It was neat and in detail as far as the reading and understanding from multiple sources I came to known oral as a receiver is negligable .. but the body related issues are only keeping my doubta alive till now ... After my last 90 days test I had intercourse with my wife like 5 times without protection and after that I became more scared and started to panic. Some websites say 6 months some say 3 months thats more confus8ng not letting me to settle down on this issue .I meet a STD specialist in the country I live he said he will not test me more .for every test I have to travel to india thats another problem . Some questions: 1.I have done 2 XXXXXXX on my 20th and 57th day some say virus will go to undetectable level is it true? 2.the 90 th day test were hiv 1/2 +p 24 is it the correct test I took 2 tests on 90th day in 2 different labs? 3.is p 24 goes to undetected level after 2 weeks is it true? 4.can I resume sex with my wife unprotected? 5. We are planning for 2nd kid its putting me in more pressure that y I dont want to infect my wife and future kid ? 7. Do you recomend more tests? Note : azithromycim I am taking weekly 3 times alternative days for skin rash amd boils as prescribed by doctor cource is over but I am having boils in my armpit for past 1 month (6 boils ) Have attached the report kindly chk and let me know .. Thanks XXXX
doctor
Answered by Dr. Sanjay Kumar Kanodia (2 hours later)
Brief Answer: No further tests are required Detailed Answer: Hello young fellow, For your further follow up questions: 1.I have done 2 XXXXXXX on my 20th and 57th day some say virus will go to undetectable level is it true? @As I guided you before regarding the HIV infection and its testing- In the entire person infected with HIV, the virus is detectable at the earliest by 2 weeks. Once it spreads into blood then it follows a phase of viremia (virus in blood ). The earliest antigen o be detected by some of the simple tests is p24. Though we can detect the complete virus by PCR test but in routinely available tests the p24 can be detected by 21 day to up to 6 weeks of period. Then the body mounts its response against the virus in form of antibodies. This antigen antibody response is manifested as the various symptoms such as fever and flu like symptoms. This phase is seen at the time of 2- 6 weeks of probable infection. The antibodies thus detected at around 6 weeks of period and up to a cut off of 3 months. As I said in my previous mail- due to previously available testing methods as well as the data available according to testing, the cut value previously was considered up to 6 months. But now the tests available in last 5 years are almost 100% sensitive test and can detect the virus and antibodies within a short span of time. AS per latest international guidelines the cut off limit is now 3 months rather than 6 months. Now XXXXXXX assay on 20th day and 57 days never can go undetectable in an infected person. It is only possible if a previously diagnosed person of HIV is on antiretroviral drugs. SO do not confuse your test result with any of the vague information. Assuming if virus had been present in yourself then it should had been detected by 20 th day itself and later on also. 2.the 90 th day test were hiv 1/2 +p 24 is it the correct test I took 2 tests on 90th day in 2 different labs? @ I think you probably have got your answer as above. At 90th day the test is more than 100 % correct. 3.is p 24 goes to undetected level after 2 weeks is it true? @ Referred as above. The earliest antigen o be detected by some of the simple tests is p24. Though we can detect the complete virus by PCR test but in routinely available tests the p24 can be detected by 21 day to up to 6 weeks of period. 4.can I resume sex with my wife unprotected? @ In my view, based on all the test reports you can very well resume your normal sex life with your wife. 5. We are planning for 2nd kid its putting me in more pressure that y I dont want to infect my wife and future kid ? @ As you can get you are not at all infected by HIV so is your wife and future kid. 7. Do you recomend more tests? @ At this juncture I do not recommend any more tests. You have gone for the best of the tests for detection of virus and all are negative. So no further tests are required. For your boils problem, If I were your treating dermatologist then would have gone for a simple culture and sensitivity test from boil area. It would have given an idea regarding exact sensitive antibiotic to be given. Dear young fellow, I can very well understand your state of mind. You are passing through a great stress. I can reassure you not just as a patient but somehow as my younger pal. I have seen so many of persons undergoing same type of stress every now and then after such kind of incidences and the things keep on haunting. But it is the simple and reliable testing facilities which actually take us out from every kind of anxiety and stress. So stop reading anything new on net related to HIV. Give yourself and your mind bit of rest. Stop thinking about HIV now. Do see a good physician for your present complaints of fever and related things. Give yourself the best positive suggestions. You have suffered for enough of 4 months and no more sufferings are required. You will be totally alright soon from your present problem. I am always there to help you further for any of your queries or if not then can close the query and rate the answer. Regards, Dr Sanjay Kumar Kanodia MD (Dermatology and Sexually transmitted diseases)
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Follow up: Dr. Sanjay Kumar Kanodia (10 hours later)
Hi doctor, Thank you for the Kind words and care.. Sure for the past 4 months my mind is full and filled with thoughts of hiv... I have gone through all the article and up to date research for cure and overly confused that I am not able to accepting the fact I negative .. Fot each test I have to travel to india from the country I Live(gulf) thats another problem .. This month have planned to meet psychologists .. Doubts: 1.It means if p 24 goes to undetectable level it means antibodues are formed correct ? I checked with that lady she says she dont have any problem she was just screened for the vis beforw 1 year and she is not a CSW she is a massage therapist in a massage parlour .but after office hours we can not gurantee wat she is doing .. Forgot to add . All the tests were performed by my SISTER advice she is working as a blood bank as a chief for past 16years. actually after my first NAAT she said I am clear I am the putting pressure on her anf telling to do all these tests . She conducted all the tests in different time and in different labs to make me believe the result but I am so filled up with fear I might infect my family still doubting the results.. Will try to come out of this .. Regards XXXX
doctor
Answered by Dr. Sanjay Kumar Kanodia (1 hour later)
Brief Answer: You are clear; start day with great zeal Detailed Answer: Dear young friend, I can totally and completely understand your part of anxiousness and as a responsible man how much you care for your family and your wife. This is the reason that you do not want to leave any stone unturned. But thanks to your sister who took all the pains to clear your doubt. I tell you that she did the best by doing XXXXXXX assay which is test beyond any doubts and is the gold standard. In all the cases of possible HIV infection we always lastly believe in this test for the earliest possible detection. To clear further of your doubts regarding p24 and antibodies- as I guided you earlier that p24 is the first antigen to be expressed and can be detected at the earliest by 3-4 weeks. It remains for around 2 weeks and then as it subsides, the antibodies start appearing. The above thing I have told you for the sake of knowledge. Now this is my personal suggestion to you to not to read any further thing on net. The important of observation in my own clinical practice is that the person with suspected HIV read so much on internet that they start feeling exactly the same as if they are suffering form the infection. This internet knowledge as well as fear regarding HIV is so high that the person is not able to come out of the aura of HIV. So also all the tests shows your clear status. The only part is the kind of guilt and anxiousness in your mind is not getting cleared from you. You know young man, we all human being s are prone to do one or other things good or bad. But sometimes the prejudice of doing wrong is so much that we do not want to believe the exact truth. In your case the truth is that you are totally clear. Give my regards to your sister who took all the pains to relieve your anxiety. Now this is my brotherly suggestion that you should not go for any further testing as well as reading for HIV and related things. Just forget the incidence as one of the past event and start everything afresh. Believe in yourself and do not sit alone. Keep a good company and keep yourself busy in work. As and when the thought of HIV comes in your mind then say to yourself that you are free form any such kind of illness. My all best wishes for future life. I would be happy to help you further for any of your queries or if not then can close the query and rate the answer. All the best. Regards, Dr Sanjay Kumar Kanodia MD (Dermatology and Sexually transmitted diseases)
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Sanjay Kumar Kanodia (2 hours later)
Hi Sir, Thank you for the supportive words. I will convey my regards to my sister . Out of anxiety i am out of control . Kindly register your self in HIV specialist .so many people will get benefited. I will come try to come out of that and first thing i should do is stop reading about it in internet . Regard's XXXX
doctor
Answered by Dr. Sanjay Kumar Kanodia (25 minutes later)
Brief Answer: My all best wishes for your future life. Detailed Answer: Hello young fellow, Even from my side I am really relaxed now that you are coming out of anxieties which you have suffered form past 4-5 months. Each and every day and nights of suffering are now abolished. The only thing required is a positive boost and a proper treatment with best diet for the present simple illness. Enjoy your day with your family and give and take whatever you have missed in last few months. My all best wishes for your future life. I hope these informations will help you. If you have further queries I will be glad to help or if not then can close the query and rate the answer. For any future of your skin or related queries you can ask me directly at: bit.ly/drsanjaykanodia "Wish you good health" Regards, Dr Sanjay Kumar Kanodia MD (Dermatology and Sexually transmitted diseases)
Note: Consult a Sexual Diseases Specialist online for further follow up- Click here.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Dr. Sanjay Kumar Kanodia

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Practicing since :2002

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Can Hiv Anti Bodies Remain Undetected Till 90 Days After Exposure?

Brief Answer: Symptoms not related to HIV Detailed Answer: Hi, Welcome and thanks for posting your query to healthcare magic. I can understand your concern for the interpretation of results of reports posted by you. After thoroughly analyzing all the reports, I first of all want to reassure you that you are not at all suffering from HIV and none of your symptoms are related to HIV, so just relax first. The first and foremost thing to tell you regarding your query is kindly rest assured about your problem as there is negligible or no risk of contracting HIV from the act of oral sex as receiving partner. Now to tell you scientifically regarding the above fact is: You do not know the status of other person- meaning whether she had HIV infection or not. So there are 50% chances of her negative status. Even if we consider positive status to HIV then you should understand that HIV is a very fragile virus and do not survive in oral mucosa (in mouth). These becomes dead as soon as it comes in contact with salivary secretions by certain enzymes in saliva. So by having oral sex even with HIV positive person does not make it sure to contract infection. It is only possible when blood from the oral mucosa of the infected person goes directly in blood of freshly cut would of the non infected person. So you can get that by oral sex the chances are itself negligible. Now even if we consider that there were if any chance of infection then your reports verify further about the totally HIV negative status of yourself. To interpret and correlate your reports: The protocol of the tests done for HIV is as follows: HIV infection can be analyzed by two ways – -A): By HIV virus detection: done by RNA- PCR. It tells us the number of copies of virus present in per ml of blood. By the latest of methods the viruses can be detected within 2 weeks of period. B): By HIV antibody Detection: the antibodies appear in maximum of 8-10 weeks then these antibodies to HIV virus persist throughout life. So if a person is tested then one HIV antibody test at 6-8 weeks and then a follow up final test at 3 months (84 days or 12 weeks) as the maximum limit. Any of these tests are not affected by any medications or antibiotics or any consumption of food or alcohol or tobacco or anything related. Now correlating all the facts let me answer all of your queries: 1.I had the habit of having chewable tobacco for past 12 years can it affect my result any how. @ No, not at all. Habit of having chewable tobacco for past 12 years can not affect test values at all. It has nothing to do with the testing. 2.I have been taking AZITHROMYCIN for the past 60 days when my test's were taken will it have any effect on my result's @ It is same for taking azithromycin too. None of the antibiotic can affect the testing of HIV. It again has nothing to do with your testing. 3.Can Hiv anti bodies remain undetected till 90 days after the contact that to after having 8 test's. @ I think you got the complete idea of testing. I personally in my own experience has never seen any body if negative at 65 days coming positive after that. So 90 days is the crystal clear limit by present day testing facilities, to declare any body as negative. 4.The bodily condition's I am facing is it related to hiv. @ Dear young man there are so many of the infections prevalent in this world which can cause similar type of illness which you have got. In my view it appears to be exaggerated upper respiratory infection which is causing all the problems. By the way azithromycin should not be consumed longer than 5 days in one course. It is totally irrational to take azithromycin for 60 days. Over and above I can make out that you are undergoing a great stress and this is one of the most important reason of getting the respiratory infection and related things prolonged. So reduce your stress otherwise it can otherwise affect your health. I personally suggest you to meet a physician at the earliest and get your self examined for the simple respiratory infection. Lastly I again reassure you for the fact that you do not have HIV infection. I hope all these informations will relax your mind. I will be glad to answer any further of your queries. Regards, Dr Sanjay Kumar Kanodia MD (Dermatology and Sexually transmitted diseases)