Heart Disease is a very broad term and includes many other diverse conditions that affect the heart. So to think that blocked arteries by plaques comprises the heart disease is not justified. Since your mention of cholesterol has come up here..it is also implicated in the etiology for clogged vessels. Actually it is the LDL.. or low density lipids that are bad.Cholesterol is a very important substance in the body, a precursor of many chemicals which are vital in the metabolic process of the body.If it levels remain within normal limits, there is safety but not necessarily,while levels above normal definitely carry a high risk. To get clogged vessels or formation of plaques is dependent on many other factors also.. which includes.exrcise. smoking, blood pressure, age,diabetes, social set up, alcohol intake,stress, dietry habits and genetic predisposition. To discuss all these here is impossible... yes it is better to have cholesterol on the lower side.. How.. I am giving you many links and beside the information from these sites may be good, but they do not replace your doctor.. that is important.. checkups from your doctor and to follow his advice is the basic rule. http://www.nlm.nih.gov/medlineplus/heartdiseases.html http://www.webmed.com/heart/default.htm http://www.heartdisease.about.com/ http://www.innovative-health.com/ http://www.search.com/dir/Top/Health/Conditions_and_Diseases/Cardiovascular_Disorders/Heart_Disease The last site will give you many other sites. Also..God created man to die in the end....And He has kept his own ways to fulfill His job!