Hi. Thanks for your query. Noted the history and understood your concerns. Detailed history is showing multiple problems as you mentioned like colonoscopy not possible, stool showing occult and frank blood, weight loss of 9 kg, anorexia, ascites , raised urea and creatitine and suffering from amoebiasis and constipation alternating with diarrhea. All these things indicate towards a possible cancer of colon with secondary changes. Hence I would advise the patient the following in such a situation: Get the correct medical treatment for amoebiasis like metronidazole or tinidazole and go for further investigations: CT scan of the whole abdomen. Barium enema studies. Retry colonoscopy and biopsy. Clinical evaluation and investigations pertaining to urology as urea and creatinine have raised by a Nephrologist. Ascitic fluid tapping for analysis. All these will lead to a proper diagnosis and gives a plan for further management.