I have been on anastrozole for a little over 4 years now due to breast cancer. I also had a TKR three years ago. I have joint pain every day, every hour; back, knee, feet, legs - everywhere. I'm thinking of stopping my anastrozole in the new few months. Are there any studies on the 5 year suggested program vs. 4 years, and what are the issues if I stop early? I was informed that my bone pain could be significantly improved within a month after stopping. My mammograms over the last 4 years have all come back normal.