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Prescribed forecox kit. What should the dosage be for ethambutol, hydrochloride, isoniazid?

my doctor prescribed me forecox kit suspecting on the basis of FNAC report, but forgot to mention dosage of the said medicine. now i am confused to see that each kit contains 3 tablets and 1 capsul, among which two tablets are identical, 2 tabs of pyrazinamide 750 mg, 1 tab of ethambutol hydrochloride 800 mg, & isoniazid 300 mg, 1 cap of Rifampicin I.P. 450 mg. now please give me proper guidance to take the course.
Asked On : Sat, 23 Jun 2012
Answers:  2 Views:  312
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General & Family Physician 's  Response
Hi, thanks for asking in Healthcare Magic.

Isoniazid (INH), Rifampicin, Ethambutol and Pyrizinamide are the first line drugs used in the treatment of tuberculosis. These drugs are tuberculocidal (kill the tubercle bacilli). The dose of INH is 300 mg, Rifampcin is 450 to 600 mg, Pyrizinamide is 1500 mg (that is why there are 2 tab) and Ethambutol is 800 to 1000 mg. Each kit contains tablets of varying dose combinations. All these tablets in the kit are taken together. Pyridoxine 10 mg should be taken daily to reduce the side effects of INH.

Revised National Tuberculosis Control Programe recommends DOTS (Directly Observed Treatment - Short course) for the treatment of tuberculosis wherein the drugs are taken only thrice a week instead of daily. This is cost effective, results in reduced side effects and improves patient's compliance (capacity to take the tablet regularly).

As per the DOTS regimen you should take the kit as follows.
1. All tablets in the kit are taken once daily, thrice a week for 2 months and followed by
2. INH and Rifampicin alone, once daily, thrice a week for 4 months.
The tablets in kit should be taken after food.

I hope this is useful to you.
Answered: Thu, 11 Apr 2013
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Internal Medicine Specialist Dr. Pankaj Malhan's  Response
Anti tubercular medication should be taken early morning before meals, most of these kits have four drugs and the whole kit needs to be taken for 2 months.As you have noticed a usual course of tuberculosis includes rifampicin 450mg, isoniazid 300, ethambutol is 800mg and you are prescribed pyrazinamide 1500 mg in the form of 750 mg 2 tabs in the morning.
All these drugs are to be taken together in the morning for 2 months , do remember to check liver functions as these can be toxic to liver.
Pyridoxine 10mg to prevent neuropathy is added to this regime.
Answered: Fri, 12 Apr 2013
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