Hello and welcome to HCM,
I will explain to you briefly the difference between tumor
suppressor genes and oncogenes.
Oncogenes are coded by proteins
Proto-oncogenes are encoded by two alleles.Mutation
of any one of the alleles converts proto-oncogene to oncogene.
Oncogene is responsible for particular malignancy.
The role of proto-oncogene in health is to keep a check on uncontrolled growth of cells.
Tumor suppressor genes are encoded by two alleles.
Mutation of both these alleles is required for development of malignancy.
Tumor suppressor genes in health also prevent development of malignancy.
Mutation of these genes may be genetic or is caused by chemicals, physical damage like radiations, etc.
Thanks and take care
Dr Shailja p Wahal