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How To Cure Side Effects Of Xenazine Prescribed For Huntington Disease?
Xenazine prescribed for Huntington Disease. Been taking 12.5mg twice daily for a couple of years. Uncontrollable movements have gotten worse, so doctor increased doseage to 25mg daily twice dailey. Side effects of taking the drug have quickly worsened. Been on new dose for about a week now. Will these side effects subside with time while the body adjusts to the new doseage?
Wed, 16 Jan 2019
Hi,
Tetrabenazine (a presynaptic dopamine depleting agent) is used in Huntington Disease-(the usual starting dose is 12.5 mg/d and the average treating dose is 25–75 mg/d), but its use may be limited by sedation and the development of secondary parkinsonism.
More recently, deuterated tetrabenazine (Austedo™) has been approved as a treatment for chorea in HD. Deuteration interferes with the metabolism of tetrabenazine and avoids a high Cmax.
In clinical trials, it has been shown to have fewer dose-related side effects than tetrabenazine and therefore can be administered in higher doses with potentially superior clinical benefits. Consult your doctor.
Hope I have answered your query. Let me know if I can assist you further.
Regards,
Dr. Tushar Kanti Biswas,
Internal Medicine Specialist
Tetrabenazine (a presynaptic dopamine depleting agent) is used in Huntington Disease-(the usual starting dose is 12.5 mg/d and the average treating dose is 25–75 mg/d), but its use may be limited by sedation and the development of secondary parkinsonism.
More recently, deuterated tetrabenazine (Austedo™) has been approved as a treatment for chorea in HD. Deuteration interferes with the metabolism of tetrabenazine and avoids a high Cmax.
In clinical trials, it has been shown to have fewer dose-related side effects than tetrabenazine and therefore can be administered in higher doses with potentially superior clinical benefits. Consult your doctor.
Hope I have answered your query. Let me know if I can assist you further.
Regards,
Dr. Tushar Kanti Biswas,
Internal Medicine Specialist
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