Hi, Methotrexate and Instaflex are two different types of medications. Methotrexate is a disease-modifying antirheumatic drug (DMARD) that is used to treat rheumatoid arthritis and other autoimmune diseases. Instaflex is a dietary supplement that contains a combination of herbal extracts and other natural ingredients that are marketed as providing joint support. It is important to discuss the use of any new supplement or medication with your healthcare provider before taking them together. In general, the safety of taking Methotrexate and Instaflex together has not been well studied, and there may be potential interactions between them. Instaflex contains several herbal ingredients, some of which may interact with Methotrexate or other medications. For example, some of the herbal ingredients in Instaflex may increase the risk of bleeding or interact with blood-thinning medications, such as aspirin or warfarin. Additionally, while Instaflex is marketed as a dietary supplement, the quality and safety of dietary supplements are not regulated by the FDA to the same extent as prescription medications. Therefore, it is important to carefully consider the potential risks and benefits of any supplement before taking it, especially if you are taking other medications or have underlying health conditions. In summary, it is important to discuss the use of Instaflex or any other new supplement with your healthcare provider before taking them together with Methotrexate or any other medication. They can advise you on the potential risks and benefits of these treatments and help you make an informed decision about your care. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Priyanka, General & Family Physician