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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Have Shakes In Hand And Legs. Have Liver Disease, Hepatic Encephalopathy And Hep C. What Causes Shaking?

My friend has end stage liver disease,and hepatic encephalopathy. She has had Hep C for years. she is slightly yellow skin and has spent the last few months in 3 hospitals and a rehab nursing hospital...She could walk a short distance and stayed at home most of the time. Since her stay in the hospital she is doing much better, but is still has symptoms but much less... She had, and still has times when she is shaking. Her hands were bad, and she could hardly eat. Her legs would bounce off the bed and she has trouble sleeping. She is on a thick liquid now. Question: What is the cause of the shakes? Is it the build up of ammonia? Thank you I am her caregiver Janet
Fri, 21 Jun 2013
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Radiologist 's  Response
Hello Janet,
Thanks for writing in.
As your friend is having hepatic encephalopathy with Heatitis C, there is decreased breakdown of nitrogeneous products in her liver. Till some point is time the body adapts top such problems and tries to balance the nitrogen waste content in blood.
Af ter a while the blood nirtogen reaches a critical level. When this level is reached, the blood becomes toxic to the brain cells. This is known as hepatic encephalopathy.
The brain then starts behaving in a strange way and tremors (shaking) are seen.
There shakes should decreas with control in blood levels of nitrogen.

Hope this helps.
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Have Shakes In Hand And Legs. Have Liver Disease, Hepatic Encephalopathy And Hep C. What Causes Shaking?

Hello Janet, Thanks for writing in. As your friend is having hepatic encephalopathy with Heatitis C, there is decreased breakdown of nitrogeneous products in her liver. Till some point is time the body adapts top such problems and tries to balance the nitrogen waste content in blood. Af ter a while the blood nirtogen reaches a critical level. When this level is reached, the blood becomes toxic to the brain cells. This is known as hepatic encephalopathy. The brain then starts behaving in a strange way and tremors (shaking) are seen. There shakes should decreas with control in blood levels of nitrogen. Hope this helps.