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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Have Crohn s disease. Taking Aza-azothioprine. Safe to try to conceive?

Hello :) My husband has Crohns Disease & we are looking at conceiving our 2nd child within the next few months. Our 1st child, my husband was not diagnosed with Crohns as he didnt have any flare ups or symptoms till after our child was born. He has been on Aza-Azothioprine for roughly a year or more. Is it safe to try to conceive or what is recommended for us? What is our best option, as I can't seem to find any findings about the safest route or recommended time to try & conceive after being on this drug? Thank you so much
Thu, 2 May 2013
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OBGYN 's  Response
Hello, I would be happy to help you with your question.

To quote from a reputable source:

"Azathioprine was found to cause....temporary depression in spermatogenesis and reduction in sperm viability and sperm count were also reported in mice."

He needs to contact a Urologist who should check a semen analysis and counsel him appropriately regarding its use and potential for decrease in fertility and affect on sperm.

I hope that this helps and good luck!

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Have Crohn s disease. Taking Aza-azothioprine. Safe to try to conceive?

Hello, I would be happy to help you with your question. To quote from a reputable source: Azathioprine was found to cause....temporary depression in spermatogenesis and reduction in sperm viability and sperm count were also reported in mice. He needs to contact a Urologist who should check a semen analysis and counsel him appropriately regarding its use and potential for decrease in fertility and affect on sperm. I hope that this helps and good luck!