Have you ever seen a patient who was allergic to titanium? I had a knee replacement 3 years ago and am plagued with severe swelling and an ugly red rash on that leg. I had the Melissa test and it showed I was allergic to titanium. Yet, several doctors have told me this is impossible and that what I have is an infection. I do not have pain, but stiffness when the swelling gets severe. My Dr. has drained it several times and found the fluid full of "rice bodies". I do NOT have Rheumatoid Arthritis. In general, I am not an allergic person, but I am allergic to eye shadow. I consulted a doctor who specializes in "revisions" and he declared it to be an infection and wants to replace it with another titanium prothesis. I just need some answers. The fluid from my knee has been cultured 8 times and never shown any infection. Any advice would be welcome.