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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Blood Test Shows Elavated Liver Enzymes. On Tramadol For Many Years For Arthritis. Side Effect?

I have taken the medication Tramadol for the past 10 years for arthritis and pain from a severe injury from an accident,also 10 years ago-I am 59-female,no diabetes or other serious health problems. My last blood tests show my liver enzymes are elevated-a friend told me that Tramadol can cause this,even in therapeutic doses(I take 2 50mg. tablets every 8 hrs.)Is this true,that Tramadol can damge the liver?
Fri, 3 May 2013
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General & Family Physician 's  Response
Hello, thanks for the query to H.C.M. Forum
Tramadol is an analgesic and most potent and a pain reliever.
Directly I would say that TRAMADOL is metabolize in LIVER.

Metabolism renders the metabolites water soluble and hence they pass in urine through.
Continue use of TRAMADOL may damage LIVER & KIDNEY.
Withdrawal also reported in Tramadol addict patients & these are as,
Uncontrolled nervous tremors,
Muscle contractures
Restless syndrome
So you decide which is the best way for you.
Regards Dr.HET
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General & Family Physician Dr. Pavan Kumar Gupta's  Response
Hello,
Tramadol is an opioid analgesic used for the therapy of mild-to-moderate pain. Tramadol overdose can cause acute liver failure.However  pharmacological use of tramadol has not been associated with cases of clinically apparent drug-induced liver disease.

It's continued use results in minor enzyme elevations which  are usually mild, asymptomatic and self-limited, resolving even with continuation of therapy.However you should keep a regular watch on your liver enzymes by constant monitoring them at regular intervals and if you find that they are increasing,you should stop TRAMADOL at once.

Since it is an opioid analgesic,it leads to addiction and it being a kidney toxic also,you should find ways to minimise it's consumption.
Thanks
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Blood Test Shows Elavated Liver Enzymes. On Tramadol For Many Years For Arthritis. Side Effect?

Hello, thanks for the query to H.C.M. Forum Tramadol is an analgesic and most potent and a pain reliever. Directly I would say that TRAMADOL is metabolize in LIVER. Metabolism renders the metabolites water soluble and hence they pass in urine through. Continue use of TRAMADOL may damage LIVER & KIDNEY. Withdrawal also reported in Tramadol addict patients & these are as, Uncontrolled nervous tremors, Muscle contractures Restless syndrome So you decide which is the best way for you. Regards Dr.HET