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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Bilirubin, SGOT/SGPT High. Prescribed Ursodeoxycholic Acid, Silymarin, Clindamycin Hydrochloride, Famotidine, Primaquine Phosphate. Correct Medication?

hi sir,I have gone through LFT test while taking treatment for jaundice and i found my bilirubin total (3.1) ,SGOT/ SGPT reading too high(1840/2040) and alkaline phosphate (348) .All others like blood counts etc are normal in reports.I do not have fever.My doctor now (prescribes me medicine which contains URSODEOXYCHOLIC ACID & SILYMARIN ,clindamycin hydrochloride,famotidine,primaquine phospate,Pls guide me whether i am taking correct medicines or not..I am 22 and dont have habit of drinking alcohol,cigars etc.
Sat, 30 Mar 2013
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Gastroenterologist 's  Response
Hello,
sudheer4b3,
Your levels of enzymes indicates that you have acute hepatitis. I hope
that your doctor has done complete hepatitis screenig for all three major
types A,B and C. If you have type A hepatitis , the enzymes should start
coming down in 4-6 weeks from the onset of jaundice. If you have type-B
Hepatitis , about 20-30% can go into a chronic phase and even after six
months , the enzymes will stay abnormal. Same could be true for Hep-C
if you have any of the risk factors.
Clindamycin is an antibiotic and is not effective for viral infection.
Urso and sylamarin may be helpful in reducing the damage to the liver.
Primaquin is also not indicated for hepatitis virus. Famotidine is a H-2 Blocker
and for acid control.
I am glad that you don't smoke or drink. You need to be on a good high protein
diet , take B-Complex Vitamin with C which is helpful.
Hope you can discuss these with your doctor.
I wish you well.
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General Surgeon Dr. Dr. Ivan Romich's  Response
Hi and welcome to hCM.
Honestly i didnt get why are you taking clyndamicin and primaquine if there is no sigh of infection.
Other drugs are used in liver and bilary/liver disease treatment,and this is ok but you need to find the exact cause of your abnormal lab tests. These are extremly high SGOT and SGPT and it means that there is a severe liver or biliary duct damage or obstruction. YOu must do ultrasound and perfrom cholecystecomy if necessary.
you probably have biliary stones,but also any kind of hepatitis should be ruled out.
WIsh you good health
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Bilirubin, SGOT/SGPT High. Prescribed Ursodeoxycholic Acid, Silymarin, Clindamycin Hydrochloride, Famotidine, Primaquine Phosphate. Correct Medication?

Hello, sudheer4b3, Your levels of enzymes indicates that you have acute hepatitis. I hope that your doctor has done complete hepatitis screenig for all three major types A,B and C. If you have type A hepatitis , the enzymes should start coming down in 4-6 weeks from the onset of jaundice. If you have type-B Hepatitis , about 20-30% can go into a chronic phase and even after six months , the enzymes will stay abnormal. Same could be true for Hep-C if you have any of the risk factors. Clindamycin is an antibiotic and is not effective for viral infection. Urso and sylamarin may be helpful in reducing the damage to the liver. Primaquin is also not indicated for hepatitis virus. Famotidine is a H-2 Blocker and for acid control. I am glad that you don t smoke or drink. You need to be on a good high protein diet , take B-Complex Vitamin with C which is helpful. Hope you can discuss these with your doctor. I wish you well.