Hello, Thanks for posting your query. I hope she is on the treatment for vascular dementia medicines already. So continue that regimen. The Seroquel is a difficult drug and may not suit some patients at all. If the patients is having mania like features then the valproic acid may be very useful but the drug may cause liver function derangement so the LFT needs to be checked frequently initially. If your physician thinks it should be given he might be thinking of managing maniac part, there is worth trying it. I hope this answers your query. In case you have any follow up queries or doubts, you can forward them for me, and I shall be glad to help you. Please accept my answer in case you do not have further queries. Wishing you good health.