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What does this P24 antigen HIV test result indicate?

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Posted on Mon, 11 May 2015
Question: Dear Sir,

I have done HIV test few Months back at your lab. Can you help in Interprating results?

What is meaning of p24 not determinable in test results?

your urgent help is appreciated

Regards
doctor
Answered by Dr. Sheetal Verma (34 minutes later)
Brief Answer:
It means HIV negative.

Detailed Answer:
Hi
Thanks for your query at HCM.
I understand your concern and situation.

The HIV duo test is used to detect HIV ANTIBODY 1/2 and P24 antigen of the HIV virus. The test can identify HIV infection through detection of the HIV-1 p24 antigen before the presentation of antibody response. This reduces the window period for detection of HIV infection by an average of 5 days (range: 2-20 days) earlier than other ELISA. The sensitivity of this test is EXCELLENT (99.99%).

You need not be worried about the comments such as not determinable. It usually is seen when there is no circulating antigen of HIV in blood. Meaning is negative. As far as the result in your case, you are HIV negative as both antigen and antibodies suggest the same. But as per international CDC norms you must get tested again between 3-6 months for confirmation.

Take care.
You can take a follow-up query.
If no clarifications then you can close the discussion and rate the answer.
Dr.Sheetal Verma
Above answer was peer-reviewed by : Dr. Shanthi.E
doctor
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Follow up: Dr. Sheetal Verma (42 minutes later)
Dear sir

I have done HIV 1 and HIV 2 RNA pcr test both came not detected after 20 days.Also repeat hiv antibody test after 95 days also come negative.

whether any more testing required

Regards
XXXXXX
doctor
Answered by Dr. Sheetal Verma (1 hour later)
Brief Answer:
At 6 months again HIV antibody test.

Detailed Answer:
Well come back.

As you have already taken the test at 3 months and it is negative. Still I suggest you to take a test at 6 months for confirmation.As window period extends to maximum at 6 months. Post that you will be at no risk whatsoever.

Take care.
Above answer was peer-reviewed by : Dr. Pradeep Vitta
doctor
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Follow up: Dr. Sheetal Verma (40 minutes later)
I have read that Normal window peroid is three Months for Antibody test and For RNA PCR test 12 days. Whether further testing is required.

See below Details for my two exposure and details of test taken up to now and symptoms appear up to now

Exposure 01

1. 12th XXXXXXX 2014 back gone to dance bar . I was wearing clothes and she weari.ng jeans and top nude. I am on top of her wearing clothes. During that period i ejaculated inside my clothes.Following test done and all negative

25th July 2014- FOURTH GENERATION TEST AND HIV -1 RNA AND HIV 2 RT PCR
13th Sep 2014 - HIV ANTOBODY TEST
22ND SEP -HIV ANTIBODY TEST
30TH SEP -HIV ANTIBODY TEST
10TH OCTOBER -4TH GENERATION TEST

Symptoms

1. big Mouth ulcers -20th August 2014
2 Seborraic dermattis very severe cause inflammation on scalp coming and going for last four Months
3 Weight loss of 4 kg -15th to 29th July 2014
4 PIles -28th July to 10th August 2014

Exposure -02-10th October 2014

During these testing period have given blood for HIV testing. But before my blood has taken sister has taken hiv postive person blood 15 to 20 minutes earlier. Sister has used new needle.My worry is that i have seen blood on sister nail.Is there any chance that blood touched needle of syringe and infected me.I am very much stressed.
30TH OCTOBER -FOURTH GENERATION TEST AND HIV -1 RNA AND HIV 2 RT PCR.
7th Nov 2014-Fourth Generation test. - States Test Results - Non reactive and p24 not determinable - Please advise
9th Nov 2014- Fourth Generation Test
1st Dec - Antibody test
28th Dec 2014 -Antibody test
12th XXXXXXX 2015- Antibody test


Symptoms

Fever with chills - 1st Dec 2014 FOR one day- Taken one dose of antibioticts and goes away.

Also I have done cd4 count

CD4 count -626
CD8 count -973
CD4 percentage - 27%
CD% -41.56
CD4/C8-0.64

All Tests are negative. But these periods i have following symptoms
1 Mouth ulcers -20th August 2014
2 Seborraic dermattis very severe cause inflammation coming and going for last four Months
3 Weight loss of 4 kg -15th to 29th July 2014
4 PIles -28th July to 10th August 2014
5 Fever for one day - 1st Dec 2014
6 Skin Postules Around Nose and Beard coming and going away

Regards
XXXX
doctor
Answered by Dr. Sheetal Verma (3 hours later)
Brief Answer:
See detailed answer.

Detailed Answer:
Hi

I understand that you got tested at 3 months post exposure but still I suggest you to get tested against at 6 months for HIV antibodies as in some patients it may be delayed until 6 months. This will be confirmation and for your psychological advantage. As for other problem it may be unrelated to HIV. You might have lost weight due to stress and anxiety. You must show for your seborrheic dermatitis to a dermatologist.We don't know what exactly causes seborrheic dermatitis. It seems to be a combination of things, including, Stress, genetic,medical conditions and medicines
Cold, dry weather.Sometimes, seborrheic dermatitis will clear up by itself. More often, it's a lifelong issue that clears and flares. It can last for years at a time, but you can control it with good skin care. All your investigations are normal and I see no cause to worry.

Best of health.

Above answer was peer-reviewed by : Dr. Vinay Bhardwaj
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Answered by
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Dr. Sheetal Verma

Infectious Diseases Specialist

Practicing since :2001

Answered : 635 Questions

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What does this P24 antigen HIV test result indicate?

Brief Answer: It means HIV negative. Detailed Answer: Hi Thanks for your query at HCM. I understand your concern and situation. The HIV duo test is used to detect HIV ANTIBODY 1/2 and P24 antigen of the HIV virus. The test can identify HIV infection through detection of the HIV-1 p24 antigen before the presentation of antibody response. This reduces the window period for detection of HIV infection by an average of 5 days (range: 2-20 days) earlier than other ELISA. The sensitivity of this test is EXCELLENT (99.99%). You need not be worried about the comments such as not determinable. It usually is seen when there is no circulating antigen of HIV in blood. Meaning is negative. As far as the result in your case, you are HIV negative as both antigen and antibodies suggest the same. But as per international CDC norms you must get tested again between 3-6 months for confirmation. Take care. You can take a follow-up query. If no clarifications then you can close the discussion and rate the answer. Dr.Sheetal Verma