Brief Answer:
Zantac 150 mg twice a day or 300 mg at bedtime.

Detailed Answer:
Hello -

I'm sorry you are having a hard time of this. Proton pump inhibitors can cause a discontinuation rebound effect.

Digestive enzymes can also cause acid reflux. Digestive enzymes such as pancreatic enzymes are naturally secreted into the small intestines, so they are not meant to be near the bottom of the esophagus.

The combination of the enzymes plus the rebound symptoms may be compounding each other.

Consider taking Zantac 150 mg twice a day, or two at bedtime if that is your worst time. Zantac (ranitidine) is an H2 receptor blocker rather than a proton pump inhibitor, and is considerably safer regarding side effects and rebound effects.

I imagine you already know the general recommendations for GERD and gastritis: eat smaller amounts at a time, avoid citrus, tomatoes, highly spiced foods, alcohol, reduce caffeine, chocolate, peppermint, and anything else that seems to increase the symptoms. Avoid lying down for 2-3 hrs after eating. Put head of bed up on blocks.

I hope this helps - I think it will. If it doesn't, then it's time to talk with your doctor and you may need to wean off of Prilosec more slowly.

I invite you to let me know how you are doing after you have given this a try for a few days.

---

Brief Answer:
Zantac.

Detailed Answer:
Yes - Zantac works differently than Prilosec and doesn't cause rebound hyperacidity the way Prilosec can. Try it for several days before deciding if it is adequate. If it is not, you may need to go back on the Prilosec and taper off slowly.

---