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What Are The Side Effects Of Mycomune And Defcort As Compared To Wysolone For Nephrotic Syndrome?

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Posted on Mon, 27 Jan 2014
Question: Hello Doctor, My Name is XXXX. My wife suffers from Nephrotic Syndrome. She was prescribed Wysolone 20 mg 4 tablets a day (total 80 mg/day) for 2 months and eventually tapered to 2.5 mg/day over a period of 7 - 8 months. She suffered a vision blur ( retinal vein occlusion) in the right eye for which she was administered Lucentis eye injection. Now , she is taking Mycomune S 360 for controlling her protein loss. however she has been advised to use Defcort 6 by the nephrologist as he says that the immunosuppressant works better along with the steroid as a combination therapy. i want to know what are the side effects of this steroid as compared to wysolone and whether she will have futrther eye problems. her BP is 140/90. PLease advice. thank you.
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Answered by Dr. Pavan Kumar Gupta (2 hours later)
Brief answer.....given below Detailed answer... Hello, Thanks for the query. I feel sorry for the problems being faced by your wife. DEFCORT ( DEFLAZACORT ) is a glucocorticoid which is derrived from prednisolone and 6 mg of DEFCORT is approximately equivalent to 5 mg of prednisolone. The datas suggest that DEFCORT has less severe side effects on bone,carbohydrate metabolism and less GI side effects and that is the reason your nephrologist has prescribed it. As far as retinal vein occlusion is concerned,some visual loss is expected after the event and extent of loss depends upon severity and site of occlusion. As far as prognosis is concerned,it is said that retinal vein occlusion recurrs in about one in six people ( either in same eye or other eye ) over the five years following on from it. It's prevention can be done by following .... Prompt and good control of blood pressure and diabetes Reduction of high cholesterol  Quitting smoking,if any Doing regular exercises And reduction of weight,if you are overweight. I hope it helps,however you may revert to me for any further query. Best of luck
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Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Dr. Pavan Kumar Gupta

General & Family Physician

Practicing since :1978

Answered : 6704 Questions

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What Are The Side Effects Of Mycomune And Defcort As Compared To Wysolone For Nephrotic Syndrome?

Brief answer.....given below Detailed answer... Hello, Thanks for the query. I feel sorry for the problems being faced by your wife. DEFCORT ( DEFLAZACORT ) is a glucocorticoid which is derrived from prednisolone and 6 mg of DEFCORT is approximately equivalent to 5 mg of prednisolone. The datas suggest that DEFCORT has less severe side effects on bone,carbohydrate metabolism and less GI side effects and that is the reason your nephrologist has prescribed it. As far as retinal vein occlusion is concerned,some visual loss is expected after the event and extent of loss depends upon severity and site of occlusion. As far as prognosis is concerned,it is said that retinal vein occlusion recurrs in about one in six people ( either in same eye or other eye ) over the five years following on from it. It's prevention can be done by following .... Prompt and good control of blood pressure and diabetes Reduction of high cholesterol  Quitting smoking,if any Doing regular exercises And reduction of weight,if you are overweight. I hope it helps,however you may revert to me for any further query. Best of luck