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Is there any interaction between Morphine and Gabapentin?

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Posted on Thu, 25 Sep 2014
Question: Yes Sir, i need to know about interactoin with Morphine and Gabapentin 300 mg.Please could you help me with this ?I have just been perscibed this medication , and have been told and read that if i am on Morphine that these two medications should not be taken together.I am a 66 yr old Female , and i go to a Pain Dr, and get injectios # 1 3rd and 4th , 4th and 5th , 5th and 6th as well the s1 also i just went today to have a codla done.I have a cervial coming up next month the injection help alot , it does'nt totaly take all the pain so thats why i am on pain medications as well as muscle relaxers for sever muscle spams .
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Answered by Dr. Matt Wachsman (4 hours later)
Brief Answer:
Not bad together.

Detailed Answer:
Hi

I am Dr Matt Wacksman, board eligible in addiction medicine.

Bottom line, they are likely to be safe together. Gabapenin does NOT have much effect on the respiratory centers nor heart. It may cause some drowsiness.
On searching The Entire Medical Literature for papers connecting morphine and gabapentin, most that connect the two are "Oh yeah, you don't need as much morphine for good pain control if you give gabapentin". They are very very often used together. Safely. And effectively. (generally with muscle relaxers). Do NOT overuse ANY of them. Overdoses, sometimes fatal have occurred with morphine and with muscle relaxers.

I should also mention, gabapentin rarely takes the pain away (but often lowers it... your type of pain, nerve pain, is one of the Better/more successful types). Morphine doesn't ever take the pain away, but nearly always makes it more bearable.

You can refer to the following article:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC0000/

Let me know if I can assist you further.
Above answer was peer-reviewed by : Dr. Vaishalee Punj
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Dr. Matt Wachsman

Addiction Medicine Specialist

Practicing since :1985

Answered : 4065 Questions

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Is there any interaction between Morphine and Gabapentin?

Brief Answer: Not bad together. Detailed Answer: Hi I am Dr Matt Wacksman, board eligible in addiction medicine. Bottom line, they are likely to be safe together. Gabapenin does NOT have much effect on the respiratory centers nor heart. It may cause some drowsiness. On searching The Entire Medical Literature for papers connecting morphine and gabapentin, most that connect the two are "Oh yeah, you don't need as much morphine for good pain control if you give gabapentin". They are very very often used together. Safely. And effectively. (generally with muscle relaxers). Do NOT overuse ANY of them. Overdoses, sometimes fatal have occurred with morphine and with muscle relaxers. I should also mention, gabapentin rarely takes the pain away (but often lowers it... your type of pain, nerve pain, is one of the Better/more successful types). Morphine doesn't ever take the pain away, but nearly always makes it more bearable. You can refer to the following article: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC0000/ Let me know if I can assist you further.