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I Want To Go To Mexico To Get The MVA

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Posted on Sat, 20 Feb 2021
Question: I want to go to Mexico to get the MVA E2 therapeutic vaccine for HPV. I am 59 years old and also have an autoimmune disease (Mixed Connective Tissue Disease with no organ involvement, just joint pain and swelling).When I emailed one of the doctors who administers the vaccines, he told me the vaccine was contraindicated for people with autoimmune diseases but did not explain why. Can you please explain why it is contraindicated and what the data is to support this? I am desperate to remove and CURE this nasty virus permanently. What is the worst thing that could happen to me if I get the vaccines?
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Follow up: Dr. Ramadevi Wani (0 minute later)
I want to go to Mexico to get the MVA E2 therapeutic vaccine for HPV. I am 59 years old and also have an autoimmune disease (Mixed Connective Tissue Disease with no organ involvement, just joint pain and swelling).When I emailed one of the doctors who administers the vaccines, he told me the vaccine was contraindicated for people with autoimmune diseases but did not explain why. Can you please explain why it is contraindicated and what the data is to support this? I am desperate to remove and CURE this nasty virus permanently. What is the worst thing that could happen to me if I get the vaccines?
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Follow up: Dr. Ramadevi Wani (30 hours later)
It has been well over 24 hours since I submitted my question and I have not gotten any response at all. Please answer the question or let me know someone is really researching it. It is most important to me to get an answer. But if you can't answer the question please say so and return my money.
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Follow up: Dr. Ramadevi Wani (0 minute later)
It has been well over 24 hours since I submitted my question and I have not gotten any response at all. Please answer the question or let me know someone is really researching it. It is most important to me to get an answer. But if you can't answer the question please say so and return my money.
doctor
Answered by Dr. Ramadevi Wani (3 hours later)
Brief Answer:
Details below.

Detailed Answer:
Hi,
Welcome to Healthcare magic.
I am Dr Ramadevi Wani. I will be answering your concerns.
There is some evidence in the literature that MVA E2 therapeutic vaccine for HPV may aggravate your autoimmune condition.
In addition, the immune response to vaccination may be diminished due to immunosuppressive therapy of the underlying disease.
This could be the reason for the doctor 's reply.
Best wishes.
Above answer was peer-reviewed by : Dr. Raju A.T
doctor
doctor
Answered by Dr. Ramadevi Wani (0 minute later)
Brief Answer:
Details below.

Detailed Answer:
Hi,
Welcome to Healthcare magic.
I am Dr Ramadevi Wani. I will be answering your concerns.
There is some evidence in the literature that MVA E2 therapeutic vaccine for HPV may aggravate your autoimmune condition.
In addition, the immune response to vaccination may be diminished due to immunosuppressive therapy of the underlying disease.
This could be the reason for the doctor 's reply.
Best wishes.
Above answer was peer-reviewed by : Dr. Raju A.T
doctor
default
Follow up: Dr. Ramadevi Wani (3 hours later)
I do not take any immunosuppressive drugs so that would not be a problem. Can you tell me where to find the literature that supports aggravation of an autoimmune condition by MVA E2? I am trying to figure out if the doctors exclude people with autoimmune diseases out of an abundance of caution. Or, if there have actually been documented cases of immune aggravation from the vaccines. Thank you so much Dr. Wani.
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Follow up: Dr. Ramadevi Wani (0 minute later)
I do not take any immunosuppressive drugs so that would not be a problem. Can you tell me where to find the literature that supports aggravation of an autoimmune condition by MVA E2? I am trying to figure out if the doctors exclude people with autoimmune diseases out of an abundance of caution. Or, if there have actually been documented cases of immune aggravation from the vaccines. Thank you so much Dr. Wani.
doctor
Answered by Dr. Ramadevi Wani (11 hours later)
Brief Answer:
Details below.

Detailed Answer:
Hi
welcome back.
Vaccines act by activating the immune system in the body.
So there is a theoretical concern that the immune response to vaccination may induce autoimmune disease exacerbations. There are certain case reports reporting the same
There is scarcity of randomised controlled trials undertaken with therapeutic vaccines in the treatment of patients with CIN 2/3 associated with HPV.
Until enough evidence is available, caution is warranted.

Pl go through this article in Journal of obstetrics & Gynecology research:

Advances in therapeutic vaccines for treating human papillomavirus‐related cervical intraepithelial neoplasia XXXXXXX Barra Luigi Della Corte XXXXXXX Noberasco XXXXXXX Foreste Gaetano Riemma XXXXXXX Di Filippo Giuseppe Bifulco XXXXXXX Orsi XXXXXXX Icardi XXXXXXX Ferrero
First published: 10 May 2020 https://doi.org/10.1111/jog.14276

Pl see the Table 1. Overview of main therapeutic vaccines for cervical cancer.


2. The information below is from another article.
HPV vaccine and ASIA syndrome
Recently, several reports have suggested grouping different autoimmune conditions that are triggered by external stimuli (e.g., exposure to vaccine) as a single syndrome called autoimmune syndrome induced by adjuvants (ASIA) [132]. This syndrome is characterized by the appearance of myalgia, myositis, muscle weakness, arthralgia, arthritis, chronic fatigue, sleep disturbances, cognitive impairment, and memory loss. This term was introduced by Yehuda Shoenfeld, who highlighted the pathogenic role of adjuvants in the induction of autoimmune syndromes: these compounds mimic evolutionarily conserved molecules (e.g., bacterial cell walls, LPS, unmethylated CpG-DNA) and bind to toll-like receptors (TLRs). They activate dendritic cells (DCs), lymphocytes, and macrophages, increasing subsequently the release of chemokines and cytokines from T-helper and mast cells [133–137]. The adjuvants added into vaccines can induce a non-specific activation of the immune system with a subsequent expansion of autoreactive (in our case, myelin specific) lymphocytes that may be further accelerated by defective regulatory cells/circuits, in genetically susceptible individuals. Indeed, the main individuals at ASIA syndrome risk are as follows: (1) patients with prior post-vaccination autoimmune phenomena, (2) patients with a medical history of autoimmunity, (3) patients with a history of allergic reactions, and individuals who are prone to develop autoimmunity (having a family history of autoimmune diseases, presence of autoantibodies, carrying certain genetic profiles, etc.) [138].

In the 2016, we retrospectively described a case series including 18 girls (aged 12–24 years) for the evaluation of “neuropathy with autonomic dysfunction” immediately after HPV vaccine [Gardasil® (9 girls) and Cervarix® (9 girls)] [139]. All girls complained of long-lasting and invalidating somatoform symptoms of the recently described ASIA syndrome (including asthenia, headache, cognitive dysfunctions, myalgia, sinus tachycardia, and skin rashes) that have developed 1–5 days (n = 11), 5–15 days (n = 5), and 15–20 days (n = 2) after the last dose vaccination. The HPV vaccine formula contains aluminum (225 e 500 μg/each dose in Gardasil® and Cervarix®, respectively) but also high polysorbate 80 (50 mcg) concentration that might also induce a greater meningeal permeability leading to a facilitated entrance of many substances to the CNS. Based upon these observations, it might be speculated that HPV vaccine could induce some abnormal activation of immune competent cells in the CNS, such as the glia.

Among the risk factors for ASIA syndrome, the metal hypersensitivity in girls, mainly genetically predisposed individuals, exposed to immunization, has been suspected. We tested five adjuvant metals (aluminum, mercury, nickel, methyl-mercury, thimerosal) in our case series through in vitro blood test and lymphocyte transformation test (MELISA®). However, the study was frustrating, being the seven girls negative to each of the five metals tested, showing a metal-hypersensitivity only in nine patients: toxicity to aluminum (two girls), reactivity to nickel (seven girls), followed by mercury (four girls) [140].

Case control and epidemiological studies and a detailed genetic analysis of affected girls and their family might better define the link between vaccination and CNS damage.

Above answer was peer-reviewed by : Dr. Prasad
doctor
doctor
Answered by Dr. Ramadevi Wani (0 minute later)
Brief Answer:
Details below.

Detailed Answer:
Hi
welcome back.
Vaccines act by activating the immune system in the body.
So there is a theoretical concern that the immune response to vaccination may induce autoimmune disease exacerbations. There are certain case reports reporting the same
There is scarcity of randomised controlled trials undertaken with therapeutic vaccines in the treatment of patients with CIN 2/3 associated with HPV.
Until enough evidence is available, caution is warranted.

Pl go through this article in Journal of obstetrics & Gynecology research:

Advances in therapeutic vaccines for treating human papillomavirus‐related cervical intraepithelial neoplasia XXXXXXX Barra Luigi Della Corte XXXXXXX Noberasco XXXXXXX Foreste Gaetano Riemma XXXXXXX Di Filippo Giuseppe Bifulco XXXXXXX Orsi XXXXXXX Icardi XXXXXXX Ferrero
First published: 10 May 2020 https://doi.org/10.1111/jog.14276

Pl see the Table 1. Overview of main therapeutic vaccines for cervical cancer.


2. The information below is from another article.
HPV vaccine and ASIA syndrome
Recently, several reports have suggested grouping different autoimmune conditions that are triggered by external stimuli (e.g., exposure to vaccine) as a single syndrome called autoimmune syndrome induced by adjuvants (ASIA) [132]. This syndrome is characterized by the appearance of myalgia, myositis, muscle weakness, arthralgia, arthritis, chronic fatigue, sleep disturbances, cognitive impairment, and memory loss. This term was introduced by Yehuda Shoenfeld, who highlighted the pathogenic role of adjuvants in the induction of autoimmune syndromes: these compounds mimic evolutionarily conserved molecules (e.g., bacterial cell walls, LPS, unmethylated CpG-DNA) and bind to toll-like receptors (TLRs). They activate dendritic cells (DCs), lymphocytes, and macrophages, increasing subsequently the release of chemokines and cytokines from T-helper and mast cells [133–137]. The adjuvants added into vaccines can induce a non-specific activation of the immune system with a subsequent expansion of autoreactive (in our case, myelin specific) lymphocytes that may be further accelerated by defective regulatory cells/circuits, in genetically susceptible individuals. Indeed, the main individuals at ASIA syndrome risk are as follows: (1) patients with prior post-vaccination autoimmune phenomena, (2) patients with a medical history of autoimmunity, (3) patients with a history of allergic reactions, and individuals who are prone to develop autoimmunity (having a family history of autoimmune diseases, presence of autoantibodies, carrying certain genetic profiles, etc.) [138].

In the 2016, we retrospectively described a case series including 18 girls (aged 12–24 years) for the evaluation of “neuropathy with autonomic dysfunction” immediately after HPV vaccine [Gardasil® (9 girls) and Cervarix® (9 girls)] [139]. All girls complained of long-lasting and invalidating somatoform symptoms of the recently described ASIA syndrome (including asthenia, headache, cognitive dysfunctions, myalgia, sinus tachycardia, and skin rashes) that have developed 1–5 days (n = 11), 5–15 days (n = 5), and 15–20 days (n = 2) after the last dose vaccination. The HPV vaccine formula contains aluminum (225 e 500 μg/each dose in Gardasil® and Cervarix®, respectively) but also high polysorbate 80 (50 mcg) concentration that might also induce a greater meningeal permeability leading to a facilitated entrance of many substances to the CNS. Based upon these observations, it might be speculated that HPV vaccine could induce some abnormal activation of immune competent cells in the CNS, such as the glia.

Among the risk factors for ASIA syndrome, the metal hypersensitivity in girls, mainly genetically predisposed individuals, exposed to immunization, has been suspected. We tested five adjuvant metals (aluminum, mercury, nickel, methyl-mercury, thimerosal) in our case series through in vitro blood test and lymphocyte transformation test (MELISA®). However, the study was frustrating, being the seven girls negative to each of the five metals tested, showing a metal-hypersensitivity only in nine patients: toxicity to aluminum (two girls), reactivity to nickel (seven girls), followed by mercury (four girls) [140].

Case control and epidemiological studies and a detailed genetic analysis of affected girls and their family might better define the link between vaccination and CNS damage.

Above answer was peer-reviewed by : Dr. Prasad
doctor
default
Follow up: Dr. Ramadevi Wani (5 hours later)
Dr. Wani,
Thank you for the articles. They were very helpful. I am still a little bit confused. Are people with autoimmune diseases more at risk of over stimulating the immune system from any vaccine regardless of type? Or is there something specific about vaccines that use live virus? If I were to get the shingles (live virus I believe) vaccine without having any negative immune reaction, is it likely that I would also not have a negative reaction to the MVAE2 vaccine?

Dr. Wani- Thank you for all your help. I am truly grateful.
default
Follow up: Dr. Ramadevi Wani (0 minute later)
Dr. Wani,
Thank you for the articles. They were very helpful. I am still a little bit confused. Are people with autoimmune diseases more at risk of over stimulating the immune system from any vaccine regardless of type? Or is there something specific about vaccines that use live virus? If I were to get the shingles (live virus I believe) vaccine without having any negative immune reaction, is it likely that I would also not have a negative reaction to the MVAE2 vaccine?

Dr. Wani- Thank you for all your help. I am truly grateful.
doctor
Answered by Dr. Ramadevi Wani (30 hours later)
Brief Answer:
Details below.

Detailed Answer:
Hi,
Welcome back.
Yes. People with autoimmune diseases are more at risk of over stimulating the immune system from any vaccine regardless of type.
The fact that you did not have negative immune reaction with shingles, does not guarantee that you will not have reaction to MVE2 vaccine.
f you have time, do go through this article.
EPMA J. 2017 Sep; 8(3): 295–311.
Published online 2017 Jul 20. doi: 10.1007/s13167-017-0101-y
PMCID: PMC0000
PMID: 0000
Vaccination and autoimmune diseases: is prevention of adverse health effects on the horizon? XXXXXXX Vadalà,corresponding author1,2 XXXXXXX Poddighe,3 XXXXXXX Laurino,1,2 and Beniamino Palmieri1,2

Best wishes.
Above answer was peer-reviewed by : Dr. Vaishalee Punj
doctor
doctor
Answered by Dr. Ramadevi Wani (0 minute later)
Brief Answer:
Details below.

Detailed Answer:
Hi,
Welcome back.
Yes. People with autoimmune diseases are more at risk of over stimulating the immune system from any vaccine regardless of type.
The fact that you did not have negative immune reaction with shingles, does not guarantee that you will not have reaction to MVE2 vaccine.
f you have time, do go through this article.
EPMA J. 2017 Sep; 8(3): 295–311.
Published online 2017 Jul 20. doi: 10.1007/s13167-017-0101-y
PMCID: PMC0000
PMID: 0000
Vaccination and autoimmune diseases: is prevention of adverse health effects on the horizon? XXXXXXX Vadalà,corresponding author1,2 XXXXXXX Poddighe,3 XXXXXXX Laurino,1,2 and Beniamino Palmieri1,2

Best wishes.
Above answer was peer-reviewed by : Dr. Vaishalee Punj
doctor
default
Follow up: Dr. Ramadevi Wani (16 hours later)
Thank you Dr. Wani for taking the time to answer my questions and for providing all the research articles to help me make an informed decision. You have been terrific!
Is it possible to work with you again in the future should I have more questions?
default
Follow up: Dr. Ramadevi Wani (0 minute later)
Thank you Dr. Wani for taking the time to answer my questions and for providing all the research articles to help me make an informed decision. You have been terrific!
Is it possible to work with you again in the future should I have more questions?
doctor
Answered by Dr. Ramadevi Wani (3 hours later)
Brief Answer:
Details below.

Detailed Answer:
Hi,
You are welcome. Happy to help you. Thank you for trusting Ask a Doctor.
Yes, definitely in future when you have questions, you can always mention in your questions
that it needs to be answered by me. The question will be forwarded to me.

Regards
Above answer was peer-reviewed by : Dr. Arnab Banerjee
doctor
doctor
Answered by Dr. Ramadevi Wani (0 minute later)
Brief Answer:
Details below.

Detailed Answer:
Hi,
You are welcome. Happy to help you. Thank you for trusting Ask a Doctor.
Yes, definitely in future when you have questions, you can always mention in your questions
that it needs to be answered by me. The question will be forwarded to me.

Regards
Note: Revert back with your gynae reports to get a clear medical analysis by our expert Gynecologic Oncologist. Click here.

Above answer was peer-reviewed by : Dr. Arnab Banerjee
doctor
Answered by
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Dr. Ramadevi Wani

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Practicing since :1985

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I Want To Go To Mexico To Get The MVA

I want to go to Mexico to get the MVA E2 therapeutic vaccine for HPV. I am 59 years old and also have an autoimmune disease (Mixed Connective Tissue Disease with no organ involvement, just joint pain and swelling).When I emailed one of the doctors who administers the vaccines, he told me the vaccine was contraindicated for people with autoimmune diseases but did not explain why. Can you please explain why it is contraindicated and what the data is to support this? I am desperate to remove and CURE this nasty virus permanently. What is the worst thing that could happen to me if I get the vaccines?