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How Long Does Norco Remain In The System?

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Posted on Mon, 29 Jun 2015
Question: how long does norco 10/325 work and last in the body?
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Answered by Dr. Panagiotis Zografakis (1 hour later)
Brief Answer:
it may last for up to 24 hours

Detailed Answer:
Hello,

acetaminophen half life is 2-4 hours. Hydrocodone half life is 3.3-4.4 hours. In order to achieve an almost complete (>96%) clearance of the drug 5-6 half lives are required. So 6 half lives for acetaminophen is 24 hours and 24-26 hours for hydrocodone. In some patients the times can be different because of individual differences.

Kind Regards!
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Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Panagiotis Zografakis

Internal Medicine Specialist

Practicing since :1999

Answered : 3809 Questions

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How Long Does Norco Remain In The System?

Brief Answer: it may last for up to 24 hours Detailed Answer: Hello, acetaminophen half life is 2-4 hours. Hydrocodone half life is 3.3-4.4 hours. In order to achieve an almost complete (>96%) clearance of the drug 5-6 half lives are required. So 6 half lives for acetaminophen is 24 hours and 24-26 hours for hydrocodone. In some patients the times can be different because of individual differences. Kind Regards!