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Does Alcohol Interact With Zoloft And Dexilant?

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Posted on Mon, 12 Jun 2017
Question: Hi, yes thyroid gland is good. They put me on Dexilant for heartburn and Zoloft for anxiety.. I take Zoloft at night and it seems to be working. I'm just curious if I could have an occasional drink with these meds n what to take with either meds if I have a headache?
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Answered by Dr. Bonnie Berger-Durnbaugh (1 hour later)
Brief Answer:
Suggestions:

Detailed Answer:
Hi XXXXXXX

I'm glad your thyroid tests were good.

Regarding an occasional alcoholic drink, the medication that alcohol can interact with is the Zoloft (sertraline). The combination can increase side effects from the sertraline such as dizziness, sleepiness, confusion, and difficulty concentrating. Some people may also experience impairment in thinking, judgment, and motor coordination. It isn't an absolute contraindication, and some people do have a small amount of alcohol on it, but I recommend trying it at home (small amount) if you are going to try it.

The other thing about alcohol is that it can be directly irritating to the stomach lining, and as you are on a proton pump inhibitor, I am guessing you may have some stomach problems to have been prescribed that. So caution there in that alcohol can make stomach problems worse.

For headaches, it's fine to take Tylenol with Zoloft and Dexilant. But do not take Tylenol or other acetaminophen products if you have alcohol, because that combination is hard on the liver and can cause inflammation or injury to it.

I hope this information helps. Please let me know if I can provide further information.
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Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Bonnie Berger-Durnbaugh

General & Family Physician

Practicing since :1991

Answered : 3134 Questions

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Does Alcohol Interact With Zoloft And Dexilant?

Brief Answer: Suggestions: Detailed Answer: Hi XXXXXXX I'm glad your thyroid tests were good. Regarding an occasional alcoholic drink, the medication that alcohol can interact with is the Zoloft (sertraline). The combination can increase side effects from the sertraline such as dizziness, sleepiness, confusion, and difficulty concentrating. Some people may also experience impairment in thinking, judgment, and motor coordination. It isn't an absolute contraindication, and some people do have a small amount of alcohol on it, but I recommend trying it at home (small amount) if you are going to try it. The other thing about alcohol is that it can be directly irritating to the stomach lining, and as you are on a proton pump inhibitor, I am guessing you may have some stomach problems to have been prescribed that. So caution there in that alcohol can make stomach problems worse. For headaches, it's fine to take Tylenol with Zoloft and Dexilant. But do not take Tylenol or other acetaminophen products if you have alcohol, because that combination is hard on the liver and can cause inflammation or injury to it. I hope this information helps. Please let me know if I can provide further information.